3,5-Di-tert-butylbromobenzene Chemical Properties

Melting point:

62-66 °C(lit.)

Boiling point:

152-156 °C(Press: 26 Torr)

Density 

1.126±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Almost white

Water Solubility 

35μg/L at 25℃

BRN 

2091559

InChI

InChI=1S/C14H21Br/c1-13(2,3)10-7-11(14(4,5)6)9-12(15)8-10/h7-9H,1-6H3

InChIKey

BUOWTUULDKULFI-UHFFFAOYSA-N

SMILES

C1(Br)=CC(C(C)(C)C)=CC(C(C)(C)C)=C1

LogP

6.7 at 25℃

CAS DataBase Reference

22385-77-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

22-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29039990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3,5-Di-tert-butylbromobenzene Usage And Synthesis

Application

3,5-Di-tert-butylbromobenzene can be used as an organic synthesis intermediate and a pharmaceutical intermediate, mainly in laboratory research and development processes and chemical and pharmaceutical synthesis processes.

Chemical Properties

White solid

Synthesis

General procedure for the synthesis of 3,5-di-tert-butylbromobenzene from 1,3,5-tri-tert-butylbenzene: In a dry and argon-flushed 250 mL three-necked round-bottomed flask, a condenser (with nitrogen inlet connector), a thermometer, a dosing funnel, and a magnetic stirring bar coated with Teflon were assembled. Under nitrogen protection, 1,3,5-tri-tert-butylbenzene (15.0 g, 61 mmol, 1.0 eq.) was dissolved in 42 mL of dichloromethane, stirred, and cooled to 0°C. The solution was then purged with an argon flushing syringe. 1.0 mL (7.8 mmol, 0.13 equiv) of antimony pentachloride (SbCl5) was added slowly using an argon-flushed syringe. Liquid bromine (4.94 mL, 96.0 mmol, 1.6 equiv) was dissolved in 20 mL of dichloromethane and transferred to the addition funnel. The entire apparatus was wrapped in aluminum foil to protect it from light. The bromine solution was slowly added dropwise (approximately 1 drop every 2 seconds) over a period of 2 hours. After the dropwise addition, stirring was continued for 3 hours at 0°C. The reaction solution was poured into a mixture of 800 g of ice and 800 mL of water and stirred for 15 minutes. Adjust to pH 8-9 by slowly adding 100 mL of 5 M aqueous sodium hydroxide under stirring. extract the aqueous phase with dichloromethane three times using a 2 L partition funnel. The organic phases were combined and washed sequentially with water, saturated aqueous sodium thiosulfate, water and brine and dried over anhydrous magnesium sulfate. Concentrated by rotary evaporation and dried under vacuum for several hours. The crude product was recrystallized from 30 mL of hot ethanol, heated to boiling and then cooled to room temperature, the solid was collected by filtration and washed three times with minimal amounts of cold ethanol. Vacuum drying gave 11.1 g (68% yield) of 1-bromo-3,5-di-tert-butylbenzene.1H NMR (500 MHz, CDCl3): δ 1.30 (s, 18H), 7.17 (d, 1H), 7.32 (s, 2H). The analytical data are in agreement with literature reports.

References

[1] Chemistry - A European Journal, 2007, vol. 13, # 16, p. 4433 - 4451
[2] Synthetic Communications, 1996, vol. 26, # 9, p. 1693 - 1697
[3] Synlett, 2017, vol. 28, # 13, p. 1548 - 1553
[4] Organic Letters, 2005, vol. 7, # 24, p. 5365 - 5368
[5] Macromolecules, 2002, vol. 35, # 14, p. 5382 - 5387

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