6-Methylpyridine-2-carbonitrile Chemical Properties

Melting point:

70-74 °C(lit.)

Boiling point:

0°C

Density 

1.08±0.1 g/cm3(Predicted)

Flash point:

0°C

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Dichloromethane, Hexane

pka

0.40±0.10(Predicted)

form 

Solid

color 

Off-white

InChI

1S/C7H6N2/c1-6-3-2-4-7(5-8)9-6/h2-4H,1H3

InChIKey

CMADFEQMYFNYCF-UHFFFAOYSA-N

SMILES

Cc1cccc(n1)C#N

CAS DataBase Reference

1620-75-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

RIDADR 

UN 3439 6.1/PG III

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

III

HS Code 

29333990

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

MSDS

• Language:English Provider:SigmaAldrich

6-Methylpyridine-2-carbonitrile Usage And Synthesis

Chemical Properties

White Solid

Uses

6-Methyl-2-pyridinecarbonitrile was used in the synthesis of zinc complexes bearing N,N′-bidentate entiopure ligands.

Uses

Intermediate in the preparation of selective cyclooxygenase-2 inhibitors and calcium antagonists

Synthesis Reference(s)

The Journal of Organic Chemistry, 48, p. 1375, 1983 DOI: 10.1021/jo00156a053

Synthesis

Steps in the preparation of 6-methyl-2-pyridinecarbonitrile:

Mix hydrobromic acid and 2-amino-6-methylpyridine under stirring conditions, keep warm; then cool the solution, add bromine Br2 to the solution, and then keep this reaction at a low temperature; then add aqueous sodium nitrite to the solution at this low temperature, and then react; at the end of the reaction cool the reaction solution down, adjust the pH with alkali, and then distill by water vapor distillation to obtain 2-bromo-6-methylpyridine; add cuprous cyanide and Lithium bromide was added to DMF with a mass of 2-5 times the mass of 2-bromo-6-methylpyridine, and then the solution was heated, and the reaction was kept warm after the addition of 2-bromo-6-methylpyridine; at the end of the reaction, the solution was cooled down, water was added, and then the product was obtained by water vapor distillation.

6-Methylpyridine-2-carbonitrile(1620-75-3)Related Product Information

• Azamethiphos
• 5-Amino-2-methylpyridine
• 2-CYANO-4-METHYLPYRIDINE
• 3-Methylpicolinonitrile
• 2,5-Dimethylpyridine
• 4-Methylpyridine
• 3-CYANO-5-METHYLPYRIDINE
• 2-Cyanopyridine
• 2,6-Lutidine
• 2-Chloro-5-chloromethylpyridine
• 5-Bromo-2-pyridinecarbonitrile
• 4-Bromomethyl-2-cyanobiphenyl
• 2-Cyano-5-methylpyridine
• 5-Bromo-6-methyl-2-pyridinecarbonitrile
• 4-CHLORO-PYRIDINE-2-CARBONITRILE
• 2-Cyano-4-fluoropyridine
• 2-Cyano-5-fluoropyridine
• 3-Bromo-2-cyanopyridine