Deslanoside
Deslanoside Basic information
- Product Name:
- Deslanoside
- Synonyms:
-
- cedilanidd
- deacetyl-lanatoside
- desacetyllanatosidec
- descetyldigilanidec
- deslanatoside
- sediranido
- Deslanoside (JP14/USP)
- Card-20(22)-enolide, 3-[(O-β-D-glucopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-O-2,6-dideoxy-β-D-ribo-hexopyranosyl-(1→4)-2,6-dideoxy-β-D-ribo-hexopyranosyl)oxy]-12,14-dihydroxy-, (3β,5β,12β)-
- CAS:
- 17598-65-1
- MF:
- C47H74O19
- MW:
- 943.08
- EINECS:
- 241-568-1
- Product Categories:
-
- Cardioglycosides & Glycosides
- Mol File:
- 17598-65-1.mol
Deslanoside Chemical Properties
- Melting point:
- 220-235°C
- alpha
- D20 +12° (c = 1.084 in 75% alc)
- Boiling point:
- 732.1°C (rough estimate)
- Density
- 1.1255 (rough estimate)
- refractive index
- 1.6500 (estimate)
- storage temp.
- 2-8°C
- solubility
- DMSO: 1 mg/ml; DMSO:PBS (pH 7.2) (1:6): 0.14 mg/ml
- form
- Solid
- pka
- 12.89±0.70(Predicted)
- color
- White to off-white
- CAS DataBase Reference
- 17598-65-1(CAS DataBase Reference)
Deslanoside Usage And Synthesis
Chemical Properties
Solution S is clear (2.2.1) and colourless (2.2.2, Method II).
Uses
Cardiotonic.
Definition
ChEBI: Deslanoside is a cardenolide glycoside that is lanatoside C with the acetoxy group replaced by a hydroxy group. It has a role as an anti-arrhythmia drug, a cardiotonic drug, a metabolite and an EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor. It is a 14beta-hydroxy steroid, a 12beta-hydroxy steroid, a cardenolide glycoside and a tetrasaccharide derivative.
brand name
Cedilanid-D (Novartis).
General Description
Deslanoside is a white crystalline powder; odourless, with a bitter taste; hygroscopic. It is slightly soluble in methanol, very slightly soluble in ethanol, and practically insoluble in water or chloroform.
Biological Activity
Deslanoside is a cardiac glycoside that has been found in D. lanata.[1] It induces ventricular tachycardia in anesthetized dogs when administered intravenously at a dose of 0.18 mg/kg.[2] Formulations containing deslanoside have been used in the treatment of congestive heart failure and cardiac arrythmias.
References
[1] Koren, G., and Soldin, S.J. Cardiac glycosides. Clin. Lab. Med. 7(3), 587-606 (1987).
[2] Ghani, M.F., and Smith, J.R. The effectiveness of magnesium chloride in the treatment of ventricular tachyarrhythmias due to digitalis intoxication. Am. Heart J. 88(5), 621-626 (1974).
[3] MALGORZATA KLYS Adam G. Determination of deslanoside in antemortem and postmortem specimens. Unusual case report[J]. Forensic science international, 1990, 45 3: Pages 231-238. DOI:10.1016/0379-0738(90)90179-3.
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