8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Basic information
- Product Name:
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- Synonyms:
-
- 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,
- 8-bromoguanosine 3:5-cyclic*monophosphate sodiu
- 8-Bromoguanosine-3,5-cyclomonophosphate sodium salt
- Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt
- 8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
- 8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5
- GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT
- BR-CGMP, NA
- CAS:
- 51116-01-9
- MF:
- C10H12BrN5NaO7P
- MW:
- 448.1
- EINECS:
- 256-993-8
- Product Categories:
-
- Cyclic Nucleotide related
- Cyclic Nucleotide Metabolism
- Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
- G Proteins and Cyclic Nucleotides
- Protein Kinase G (PKG)
- Serine/Threonine Kinase Activators
- Mol File:
- 51116-01-9.mol
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Chemical Properties
- storage temp.
- -20°C
- solubility
- H2O: 100 mg/mL
- form
- powder
- Water Solubility
- Soluble to 100 mM in water
Safety Information
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 29349990
MSDS
- Language:English Provider:SigmaAldrich
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Usage And Synthesis
Description
8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Chemical Properties
White powder
Uses
8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.
Definition
ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).
Biological Activity
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .
storage
Desiccate at -20°C
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATESupplier
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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE(51116-01-9)Related Product Information
- Guanosine 5'-monophosphate disodium salt
- Guanosine
- ADP
- 2-BROMO-4-METHYL-1H-IMIDAZOLE
- 2-BROMO-1-ETHOXYMETHYLIMIDAZOLE
- 8-BROMO-2'-DEOXYGUANOSINE
- GUANOSINE 3':5'-CYCLIC MONOPHOSPHATE SODIUM SALT
- 8-Bromoguanosine
- 2-Bromo-1-methyl-1H-imidazole
- 2-BROMO-1,4-DIMETHYL-1H-IMIDAZOLE
- 8-BR-CGMP
- 8-BR-PET-CGMP SODIUM SALT
- INOSINE-3',5'-CYCLIC PHOSPHATE
- 8-BROMOGUANINE
- 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
- 8-BROMOHYPOXANTHINE
- 2'-DCGMP SODIUM SALT
- 9-((2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl)guanine P-oxide