Basic information Safety Supplier Related

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE

Basic information Safety Supplier Related

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Basic information

Product Name:
8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE
Synonyms:
  • 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,
  • 8-bromoguanosine 3:5-cyclic*monophosphate sodiu
  • 8-Bromoguanosine-3,5-cyclomonophosphate sodium salt
  • Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt
  • 8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM
  • 8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5
  • GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT
  • BR-CGMP, NA
CAS:
51116-01-9
MF:
C10H12BrN5NaO7P
MW:
448.1
EINECS:
256-993-8
Product Categories:
  • Cyclic Nucleotide related
  • Cyclic Nucleotide Metabolism
  • Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology
  • G Proteins and Cyclic Nucleotides
  • Protein Kinase G (PKG)
  • Serine/Threonine Kinase Activators
Mol File:
51116-01-9.mol
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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Chemical Properties

storage temp. 
-20°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
White to off-white
Water Solubility 
Soluble to 100 mM in water
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Safety Information

WGK Germany 
3
10-21
HS Code 
29349990

MSDS

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8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE Usage And Synthesis

Description

8-bromo-Cyclic GMP (8-bromo-cGMP) is a cell-permeable analog of cGMP that exhibits greater resistance to hydrolysis by phosphodiesterases than its parent compound. It preferentially activates cGMP-dependent protein kinase. At 1 μM-0.1 mM, 8-bromo-cGMP can inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Chemical Properties

White powder

Uses

8-bromo-cGMP activates cGMP-dependent protein kinase. It can also inhibit acetylcholine-induced increases in intracellular calcium concentrations.

Definition

ChEBI: Sodium 8-bromo-3',5'-cyclic GMP is an organic sodium salt having 8-bromoguanosine 3',5'-cyclic phosphate as the counterion. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. It has a role as a protein kinase G agonist and a muscle relaxant. It contains an 8-bromo-3',5'-cyclic GMP(1-).

Biological Activity

Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1 α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro .

storage

Desiccate at -20°C

8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATESupplier

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