2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine Chemical Properties

Melting point:

142-146 °C

Boiling point:

279.7±23.0 °C(Predicted)

Density 

1.18±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO, Methanol

pka

8.89±0.40(Predicted)

form 

Solid

color 

Pale Yellow

2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine Usage And Synthesis

Description

2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is a nonpeptidic angiotensin II receptor antagonist whose imidazo[4,5-b]pyridine scaffold has been used to examine a variety of positional substitutions in the development of orally active, long duration antihypertensive agents.

Chemical Properties

Off-white powder

Uses

2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine is used as building block in chemical synthesis. Attributes Development Product Contact

Uses

2-Ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridine (cas# 133240-06-9) is a compound useful in organic synthesis.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 5775, 1994 DOI: 10.1016/S0040-4039(00)78181-0

in vitro

in a previous study, 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was synthezed by reduction of 2-amino-3-nitropyridine derivatives to the corresponding diaminopyridine which was then condensed with an appropriate carboxylic acid in polyphosphoric acid. in vitro activity study showed that 2-ethyl-5,7-dimethyl-3h-imidazo[4,5-b]pyridine was a nonpeptidic angiotensin ii receptor antagonist whose imidazo[4,5-b]pyridine scaffold had been used to examine plenty of positional substitutions in the development of orally active, long duration antihypertensive agents [1].

References

[1] mantlo, n. b.,chakravarty, p.k.,ondeyka, d.l., et al. potent, orally active imadazo[4,5-b]pyridine-based angiotensin ii receptor antagonists. journal of medicinal chemistry 34(9), 2919-2922 (1991).

2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine(133240-06-9)Related Product Information

• 5-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE
• 5,7-DIMETHYL-2-ETHYL-3-[[4-[2(N-BUTYLOXYCARBONYLSULFONAMIDO)-5-ISOBUTYL-3-THIENYL]PHENYL]METHYL]IMIDAZO[4,5,6]PYRIDINE
• MK 996
• 2-Ethyl-5,7-diMethyl-3H-iMidazo[4,5-b]pyridine