2-Bromo-4-fluorobenzaldehyde Chemical Properties

Melting point:

61.5

Boiling point:

234.9±20.0 °C(Predicted)

Density 

1.70

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

color 

White to Light yellow

InChI

InChI=1S/C7H4BrFO/c8-7-3-6(9)2-1-5(7)4-10/h1-4H

InChIKey

OPZDXMCOWFPQPE-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(F)C=C1Br

CAS DataBase Reference

59142-68-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-52-36-22

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HazardClass 

IRRITANT, LIGHT SENSITIVE

HS Code 

29122990

2-Bromo-4-fluorobenzaldehyde Usage And Synthesis

Chemical Properties

White to light yellow solid

Uses

2-Bromo-4-fluorobenzaldehyde used as pharmaceutical intermediates.It could be the starting material to synthesise 2-Bromo-4-fluorobenzonitrile, 6-Fluoroisobenzofuran-1(3H)-one, etc.

Synthesis

The general procedure for the synthesis of 2-bromo-4-fluorobenzaldehyde from 2-bromo-4-fluorobenzyl alcohol was as follows: benzyl alcohol substrate (0.2 mmol), FeCl3-6H2O (0.002 mmol, 5.4 mg) and triphenylmethanol (0.2 mmol, 52 mg) were mixed in a dry reaction vessel. Subsequently, the reaction mixture was irradiated in a microwave reactor at 55 °C for 1 hour. Upon completion of the reaction, the crude product was purified by fast column chromatography to afford the target product 2-bromo-4-fluorobenzaldehyde.

References

[1] Tetrahedron, 2015, vol. 71, # 38, p. 6744 - 6748
[2] Synthesis (Germany), 2013, vol. 45, # 24, p. 3387 - 3391

2-Bromo-4-fluorobenzaldehyde(59142-68-6)Related Product Information

• 2-Bromo-4-fluorophenol
• 2-Bromo-4-fluorobenzoic acid
• Florfenicol
• 4-Fluorobenzaldehyde
• Transfluthrin
• 1,2-Difluorobenzene
• 4-Bromofluorobenzene
• Bromine
• 3-BROMO-4-FLUOROBENZALDEHYDE,3-Bromo-4-fluorobenzaldehyde98%,3-Bromo-4-fluorobenzaldehyde 98%
• FENFLURAMINE
• 2'-BROMO-4'-FLUOROACETOPHENONE
• METHYL 2-BROMO-4-FLUOROBENZOATE
• 2-Bromo-3,4,5,6-tetrafluorobenzoic acid
• 2-BROMO-4,5-DIFLUOROBENZOIC ACID
• 2-BROMO-3,4,5,6-TETRAFLUOROBENZOYL CHLORIDE
• 4-Bromo-2-fluorobenzaldehyde 98%,4-BROMO-2-FLUOROBENZALDEHYDE,4-Bromo-2-Fluorobenzaldehyde 2-Fluoro-4-Bromobenzaldehyde,4-Bromo-2-fluorobenzaldehyde98%
• 2-BROMO-6-FLUOROBENZALDEHYDE
• 2-BROMO-4-FLUORO-5-METHYL BENZALDEHYDE