3-BENZYLOXYBROMOBENZENE Chemical Properties

Melting point:

57-60 °C

Boiling point:

333.5±17.0 °C(Predicted)

Density 

1.382±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

Solid

color 

White

InChI

InChI=1S/C13H11BrO/c14-12-7-4-8-13(9-12)15-10-11-5-2-1-3-6-11/h1-9H,10H2

InChIKey

HVWZMGZBJCJDOX-UHFFFAOYSA-N

SMILES

C1(Br)=CC=CC(OCC2=CC=CC=C2)=C1

CAS DataBase Reference

53087-13-1(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N

Risk Statements 

36/37/38-50/53-43-41

Safety Statements 

26-36/37/39-50/53-43-41-61-60

RIDADR 

UN 3077 9/PG 3

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29093090

3-BENZYLOXYBROMOBENZENE Usage And Synthesis

Chemical Properties

Whitetolightyellowcrystalpowde

Synthesis

1. Anhydrous potassium carbonate (37.32 g, 270 mmol) and benzyl chloride (11.50 mL, 99 mmol) were added to a suspension of anhydrous ethanol (300 mL) containing m-bromophenol (15.57 g, 90 mmol) under nitrogen protection. The reaction mixture was heated to reflux for 4 hours. After completion of the reaction, the ethanol was removed by vacuum filtration and evaporation. The residue was extracted with ethyl acetate (EtOAc) and the combined organic layers were washed sequentially with water, 2 M NaOH solution, saturated brine and 2 M HCl solution, dried over anhydrous sodium sulfate (Na2SO4) and concentrated to give the yellow solid product 3-benzyloxybromobenzene (22.02 g, 93%). 2. To a 250 mL two-necked round-bottomed flask, protected by nitrogen, were added dry magnesium chips (2.18 g, 90 mmol) and trace iodine, equipped with two rubber septa and stirred. Anhydrous tetrahydrofuran (THF, 40 mL) solution of 3-benzyloxybromobenzene (15.79 g, 60 mmol) was slowly added through a syringe and kept at reflux. After addition, stirring was continued at reflux for 5 hours. After the reaction mixture was cooled to -30°C, anhydrous THF (60 mL) solution of trimethyl borate (9.36 g, 90 mmol) was slowly added. After addition, the mixture was stirred at room temperature overnight, followed by treatment with saturated ammonium chloride (NH4Cl) solution and continued stirring at room temperature for 1 hour. THF was removed by rotary evaporation, the aqueous layer was extracted with EtOAc, dried over anhydrous Na2SO4, filtered and concentrated to give a yellow crude product. The crude product was purified by recrystallization in water to give white solid target product (7.53 g, 55%).

References

[1] Journal of Materials Chemistry, 2010, vol. 20, # 15, p. 3069 - 3078
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 5, p. 1044 - 1054
[3] Journal of Medicinal and Pharmaceutical Chemistry, 1962, vol. 5, p. 752 - 762
[4] Patent: US5447656, 1995, A
[5] Patent: EP838461, 1998, A2

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