(S)-5-Hydroxymethyldihydrofuran-2-one Chemical Properties

Melting point:

72-74 °C

alpha 

56 º (c=3 in chloroform)

Boiling point:

110-115 °C/0.2 mmHg (lit.)

Density 

1.237 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.471(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

pka

14.12±0.10(Predicted)

form 

clear liquid

color 

Colorless to Almost colorless

optical activity

[α]20/D +56°, c = 3 in chloroform

BRN 

1680284

CAS DataBase Reference

32780-06-6(CAS DataBase Reference)

NIST Chemistry Reference

(S)-(+)-2',3'-dideoxyribonolactone(32780-06-6)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

23-24/25-37/39-26

WGK Germany 

3

HS Code 

29322090

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

(S)-5-Hydroxymethyldihydrofuran-2-one Usage And Synthesis

Chemical Properties

Colorless to light yellow liqui

Uses

(S)-(+)-Dihydro-5-(hydroxymethyl)-2(3H)-furanone can be used as a chiral synthon to synthesize:

• Potent nucleoside, acetylcholine, and (+)-muricatacin analogs.
• Mevinic acids, which are LDL cholesterol-lowering agents.
• Adenine based anti-HIV agent named β-F-ddA.

General Description

Dihydro-5-(hydroxymethyl)-2(3H)-furanone is a chiral building block widely used in the synthesis of many natural products and few biologically significant compounds like anti-HIV dideoxynucleosides. It is also used in the synthesis of optically active ligands.

(S)-5-Hydroxymethyldihydrofuran-2-one(32780-06-6)Related Product Information

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• Tris(hydroxymethyl)aminomethane
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• 2-Hydroxyethyl methacrylate
• CARBOXYMETHYLCELLULOSE SODIUM SALT
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