POBN
POBN Basic information
- Product Name:
- POBN
- Synonyms:
-
- α-(4-Pyridyl N-oxide)-N-tert-butylnitrone,N-(4-Pyridylmethylene)-tert-butylamine N,N′-dioxide, N-tert-Butyl-α-(4-pyridyl)nitrone N′-oxide, POBN
- alpha-(4-Pyridyl 1-oxide)-N-tert-butyl-nitrone, 99% 100MG
- N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide
- POBN, N-tert-Butyl-α-(4-pyridyl)nitrone Nμ-oxide, N-(4-Pyridylmethylene)-tert-butylamine N,Nμ-dioxide
- 2-Methyl-N-[(pyridine 1-oxide)-4-ylmethylene]-2-propanamine oxide
- 4-Pyridyl-1-oxide-tert-butyl Nitrone
- N-[(Pyridine 1-oxide)-4-ylmethylene]-tert-butylamineN-oxide
- N-[[(Pyridine-1-oxide)-4-yl]methylene]-1,1-dimethylethanamine-N-oxide
- CAS:
- 66893-81-0
- MF:
- C10H14N2O2
- MW:
- 194.23
- EINECS:
- 266-512-3
- Product Categories:
-
- Analytical Chemistry
- ESR Spectrometry
- Spin Trapping Reagents
- Analytical Reagents
- Analytical/Chromatography
- Building Blocks
- C10
- Chemical Synthesis
- Electron Spin Resonance (ESR/EPR) Spectroscopy
- Heterocyclic Building Blocks
- Pyridines
- Spectroscopy
- Mol File:
- 66893-81-0.mol
POBN Chemical Properties
- Melting point:
- 183-185 °C(lit.)
- Boiling point:
- 330.68°C (rough estimate)
- Density
- 1.1444 (rough estimate)
- refractive index
- 1.5000 (estimate)
- storage temp.
- room temp
- solubility
- water: soluble10mg/mL, clear, colorless to faintly yellow
- form
- White to off-white or colorless crystalline solid.
- pka
- 0.76±0.53(Predicted)
- color
- White to Light yellow
- BRN
- 1453764
Safety Information
- Safety Statements
- 22-24/25
- WGK Germany
- 3
- HS Code
- 29333999
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
POBN Usage And Synthesis
Chemical Properties
white to pale yellow crystalline powder
Uses
Spin trap reagent used to measure ethanol oxidation to 1-hydroxyethyl radical (HER) which can bind to protein. Has also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide. The formation of hydroxyl radical in chondrocytes and cartilage has been detected using POBN.
Uses
POBN is a cell permeable hydrophilic spin trap for in vitro studies. It is a water soluble analog of PBN with low paramagnetic impurities and does not require any further purification. POBN has also also been used in studies of DNA methylation, iron-mediated polyunsaturated fatty acid peroxidation, and free-radical formation by Alzheimer β-amyloid peptide.
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