1-Aminohydantoin hydrochloride Chemical Properties

Melting point:

201-205 °C(lit.)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly, Heated)

form 

Crystalline Powder

color 

Pale yellow

biological source

mouse

BRN 

3699376

Stability:

Unstable in Solution

CAS DataBase Reference

2827-56-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

HS Code 

29332100

MSDS

• Language:English Provider:SigmaAldrich

1-Aminohydantoin hydrochloride Usage And Synthesis

Chemical Properties

Pale Yellow Powder

Uses

A metabolite of Nitrofuran.

Uses

Reactant for synthesis of: Ectoparasiticidal drugs1 Skeletal muscle relaxants2Reactant for: Suzuki-Miyaura coupling3 Lymphoid specific tryosine phosphatase inhibitor4 Proteasome inhibition by peptide semicarbazones5

Uses

1-Aminohydantoin hydrochloride may be used as one of the reactants in the synthesis of (E)-1-(2-hydroxybenzylideneamino)imidazolidine-2,4-dione, dantrolene and dantrolene sodium.

Biological Activity

Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) activates the extrinsic apoptotic pathway by binding death receptors (DR) 4 and 5. In addition to DR 4 and 5, TRAIL activates several other receptors such as decoy receptor (DcR)1, DcR2 and a soluble receptor called osteoprotegerin. TRAIL plays a vital role in the inhibition of autoimmune inflammation and cell cycle progression. TRAIL selectively kills tumor cells without damaging normal tissues and therefore, it might act as a tumor-selective anticancer agent. TRAIL-induced apoptosis is involved in various cellular processes including activation-induced cell death, homeostasis, intrathymic negative selection, autoimmunity suppression, and immune surveillance. Repeated dosage of recombinant soluble TRAIL triggers apoptosis, inhibits tumor progression, and increases viability of mice suffering from cancer.

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