HISPIDULIN
HISPIDULIN Basic information
- Product Name:
- HISPIDULIN
- Synonyms:
-
- SCUTELLAREIN 6-METHYL ETHER
- 4',5,7-Trihydroxy-6-methoxyflavone
- 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
- 6-Methoxyapigenin
- 6-Methylscutellarein
- Hispidulin(Dinatin)
- Methoxyapigenin
- Dinatin
- CAS:
- 1447-88-7
- MF:
- C16H12O6
- MW:
- 300.26
- Product Categories:
-
- Miscellaneous Natural Products
- Mol File:
- 1447-88-7.mol
HISPIDULIN Chemical Properties
- Melting point:
- 291-292 °C
- Boiling point:
- 601.5±55.0 °C(Predicted)
- Density
- 1.512±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: soluble20mg/mL, clear
- form
- powder
- pka
- 6.51±0.40(Predicted)
- color
- white to beige
HISPIDULIN Usage And Synthesis
Uses
Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
Definition
ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biological Activity
Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
Biochem/physiol Actions
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.
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HISPIDULIN(1447-88-7)Related Product Information
- Tangeretin
- APIGENIN 6-GLUCOSYL-7-O-METHYL ETHER
- cirsimaritin
- 6,7-DIMETHOXY-3',4',5-TRIHYDROXYFLAVONE
- 3'-BENZYLOXY-4',5,6,7-TETRAMETHOXYFLAVONE
- 3',4',5',5,6,7-HEXAMETHOXYFLAVONE
- 6-METHOXYLUTEOLIN
- HISPIDULIN
- CASTICIN
- HINOKIFLAVONE
- 3',5-DIHYDROXY-4',6,7-TRIMETHOXYFLAVONE
- EUPATORIN-5-METHYL ETHER
- SCUTELLAREIN TETRAMETHYL ETHER
- 3',4',5',6,7,8-HEXAMETHOXY-5-HYDROXYFLAVONE
- SCUTELLAREIN
- salvigenin
- SINENSETIN
- 3,3',4',5,6,7,8-heptamethoxyflavone