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HISPIDULIN

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HISPIDULIN Basic information

Product Name:
HISPIDULIN
Synonyms:
  • SCUTELLAREIN 6-METHYL ETHER
  • 4',5,7-Trihydroxy-6-methoxyflavone
  • 5,7-Dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
  • 6-Methoxyapigenin
  • 6-Methylscutellarein
  • Hispidulin(Dinatin)
  • Methoxyapigenin
  • Dinatin
CAS:
1447-88-7
MF:
C16H12O6
MW:
300.26
Product Categories:
  • Miscellaneous Natural Products
Mol File:
1447-88-7.mol
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HISPIDULIN Chemical Properties

Melting point:
291-292 °C
Boiling point:
601.5±55.0 °C(Predicted)
Density 
1.512±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
DMSO: soluble20mg/mL, clear
form 
powder
pka
6.51±0.40(Predicted)
color 
white to beige
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
RTECS 
DJ2996000
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HISPIDULIN Usage And Synthesis

Uses

Hispidulin has been used as a calibration standard:

  • in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
  • in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
  • in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)

Definition

ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.

General Description

This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG

Biological Activity

Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.

Biochem/physiol Actions

Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.

HISPIDULINSupplier

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