LDAO Chemical Properties

Melting point:

132-133 °C(lit.)

Boiling point:

371.32°C (rough estimate)

Density 

0.996 g/mL at 20 °C

vapor pressure 

0Pa at 25℃

refractive index 

n20/D 1.378

Flash point:

113°C (closed cup)(235

storage temp. 

-20°C

solubility 

Ethanol:15.0(Max Conc. mg/mL);65.38(Max Conc. mM)
DMF:3.0(Max Conc. mg/mL);1.31(Max Conc. mM)
DMSO:0.1(Max Conc. mg/mL);0.44(Max Conc. mM)
PBS (pH 7.2):0.1(Max Conc. mg/mL);0.44(Max Conc. mM)

form 

A crystalline solid

pka

4.79±0.40(Predicted)

Specific Gravity

0.97

Water Solubility 

Insoluble in water.

Sensitive 

Hygroscopic

BRN 

1769927

Stability:

Stable. Incompatible with strong oxidizing agents. Combustible.

LogP

1.85 at 20℃

EPA Substance Registry System

Lauryldimethylamine oxide (1643-20-5)

Safety Information

Hazard Codes 

C

Risk Statements 

34-52/53

Safety Statements 

26-36/37/39-45-27

RIDADR 

UN 3259 8/PG 2

WGK Germany 

2

RTECS 

JR6650000

F 

3-10

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29299090

Hazardous Substances Data

1643-20-5(Hazardous Substances Data)

Toxicity

mouse,LD50,intraperitoneal,375mg/kg (375mg/kg),French Medicament Patent Document. Vol. #4264M,

MSDS

• Language:English Provider:SigmaAldrich

LDAO Usage And Synthesis

Chemical Properties

Clear yellow Liquid

Uses

Barlox(R) 1260 is a concentrated cocoamine oxide surfactant. Barlox(R) 1260 can be used in a broad number of industriual cleaning applications where coupling, high foaming, detergency and compatibility are important. Product Data Sheet

Uses

LDAO is suitable to use in crystallization of membrane proteins. It is also suitable to enhance the detection of high molecular weight proteins.

Definition

ChEBI: Dodecyldimethylamine N-oxide is a tertiary amine oxide resulting from the formal oxidation of the amino group of dodecyldimethylamine. It has a role as a plant metabolite and a detergent. It derives from a hydride of a dodecane.

Application

Lauryldimethylamine oxide(LDAO) is mainly used in cosmetic and personal care product formulations, particularly in hair care products as a foaming agent, fragrance ingredient, viscosity builder, stabiliser, conditioner, emulsifier, wetting agent and antistatic agent. It is also a biochemical reagent and can be used as a biological material or organic compound for life science related research.

General Description

Crystalline solid.

Air & Water Reactions

Hygroscopic .

Reactivity Profile

LDAO is less basic than the tertiary amine from which LDAO is derived, but still reacts with strong acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Fire Hazard

Flash point data for LDAO are not available. LDAO is probably nonflammable.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

LDAO can be used to disrupt phospholipid bilayer of cells.

Purification Methods

Crystallise the oxide from acetone or ethyl acetate. [Bunton et al. J Org Chem 52 3832 1987, Beilstein 4 III 410, 4 IV 798.]

LDAO(1643-20-5)Related Product Information

• N,N-Dimethyldodecylamine
• Phosphoric acid, dodecyl ester, potassium salt
• Lauryl betaine
• Ammonium lauryl sulfate
• Sodium lauryl polyoxyethylene ether sulfate
• ETHYL LAUROYL ARGINATE HCL
• Dodecyltrimethylammonium Bromide
• Lauramidopropyl betaine
• Dodecyltrimethylammonium chloride
• Dodecylpyridinium chloride
• DODECYLMETHYLSILOXANE, 2-PHENYLPROPYLMETHYLSILOXANE COPOLYMER
• Sodium lauryl ether sulfate
• LAUROPHENONE
• Myrcene
• Lauric acid
• Lauryl glucoside
• Laurocapram
• CETYLDIMETHYLETHYLAMMONIUM BROMIDE