ISOPROPYL GLYCOLATE Chemical Properties

Boiling point:

159.3±8.0 °C(Predicted)

Density 

1.050±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

13.21±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

Water Solubility 

Slightly soluble in water.

Safety Information

HS Code 

2918199890

MSDS

• Language:English Provider:ALFA

ISOPROPYL GLYCOLATE Usage And Synthesis

Uses

Isopropyl glycolate is used as pharmaceutical intermediate.

Synthesis

The general procedure for the synthesis of isopropyl hydroxyacetate from dimethyl oxalate was as follows: first, the hydrogenation of the ester compound was carried out using bipyridyltetraethylruthenium complex 5 as a catalyst. The specific reaction conditions were as follows: the ratio of substrate to catalyst (S/C) was 1000, the amount of substrate was 3.0 mmol, the amount of catalyst 5 was 3.0 μmol, the solvent was 3.0 mL of isopropanol (iPrOH), and 0.3 mmol of sodium methanol (NaOMe) was added as the base, and the hydrogen pressure was 5 MPa, and the temperature of the reaction was 25 ℃. The reaction results are detailed in Table 2, which lists the hydrogenation results of other ester compounds under the same conditions.

References

[1] Patent: CN103980317, 2017, B. Location in patent: Paragraph 0098; 0099; 0100; 0102; 0104

ISOPROPYL GLYCOLATE(623-61-0)Related Product Information

• D-(+)-GLUCONO-1,5-LACTONE
• diisopropyl oxalate
• Ascorbyl Palmitate
• D-GLUCOHEPTONO-1,4-LACTONE
• EUCATROPINE HYDROCHLORIDE
• Diisopropyl D-tartrate
• Erythorbic Acid
• D-(-)-Gulonic acid gamma-lactone
• lifibrate
• 3-Hydroxy-4-methyl-5-ethyl-2(5H)furanone
• Homatropine Hydrobromide
• D-SACCHARIC ACID 1,4-LACTONE
• (+)-5,6-O-Isopropylidene-L-ascorbic acid
• 2-hydroxypropionicacid,isopropylester
• Glycolic acid
• ALPHA,BETA-GLUCOOCTANOIC GAMMA-LACTONE
• DI-TERT-BUTYL OXALATE
• TERT-BUTYL ALPHA-HYDROXYISOBUTYRATE