1-PHENYL-2-THIOUREA Chemical Properties

Melting point:

145-150 °C(lit.)

Boiling point:

266.7±23.0 °C(Predicted)

Density 

1.3

refractive index 

1.5500 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

Soluble in alcohol

pka

13.12±0.70(Predicted)

form 

Crystalline Powder

color 

Off-white to beige

Water Solubility 

Soluble in hot water and alcohol.

Merck 

14,7315

BRN 

907309

Stability:

Stable. Incompatible with strong acids, strong oxidizing agents, strong bases.

CAS DataBase Reference

103-85-5(CAS DataBase Reference)

EPA Substance Registry System

Phenylthiourea (103-85-5)

Safety Information

Hazard Codes 

T+

Risk Statements 

28-43

Safety Statements 

28-36/37-45

RIDADR 

UN 2811 6.1/PG 1

WGK Germany 

3

RTECS 

YU1400000

TSCA 

Yes

HazardClass 

6.1

PackingGroup 

I

HS Code 

29309090

Hazardous Substances Data

103-85-5(Hazardous Substances Data)

Toxicity

LD50 in rats, rabbits (mg/kg): 3, 40 orally (Scheline)

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

1-PHENYL-2-THIOUREA Usage And Synthesis

Chemical Properties

white crystalline powder

Chemical Properties

N-phenylthiourea is a colorless crystalline solid.

Uses

1-Phenylthiourea is used as a reactant in the preparation of disubstituted thiazoles as potential antibacterial and antiinflammatory agents via condensation of phenacyl bromide with thioureas and thiosemicarbazones.

Uses

In medical genetics.

Definition

ChEBI: N-phenylthiourea is a member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing. It has a role as an EC 1.14.18.1 (tyrosinase) inhibitor. It is functionally related to a thiourea.

General Description

Needle-like crystals. Used in the manufacture of rodenticides and in medical genetics.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

1-PHENYL-2-THIOUREA is incompatible with strong oxidizers, strong acids and strong bases. 1-PHENYL-2-THIOUREA emits toxic fumes on contact with acid fumes.

Health Hazard

1-PHENYL-2-THIOUREA is classified as extremely toxic. The probable oral lethal dose is 5-50 mg/kg or between 7 drops and 1 teaspoon for a 70 kg (150 lb.) person.

Fire Hazard

Dangerous disaster hazard; emits toxic fumes of oxides of sulfur and nitrogen when heated to decomposition. Avoid acids or acid fumes.

Potential Exposure

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Contact with acids or acid fumes produces toxic fumes of sulfur oxide.

Purification Methods

Crystallise the thiourea from water and dry it at 100o in air. [Beilstein 12 IV 804.]

Incompatibilities

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 24
48 hours after breathing overexposure, as pulmonary edema may be delayed. As first aid for pulmonary edema, a doctor or authorized paramedic may consider administering a drug or other inhalation therapy.

Waste Disposal

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

1-PHENYL-2-THIOUREA(103-85-5)Related Product Information

• 1-(2-Chlorophenyl)-2-thiourea
• 1-PHENYL-2-THIOUREA
• 1,3-Diphenyl-2-thiourea
• 1-DODECYL-3-PHENYL-2-THIOUREA
• 4-PHENYL-3-THIOSEMICARBAZIDE
• 1-(3,4-DICHLOROPHENYL)-2-THIOUREA
• 1-CYCLOHEXYL-3-PHENYL-2-THIOUREA
• 1,4-DIPHENYL-3-THIOSEMICARBAZIDE
• 4,4'-DIMETHYLTHIOCARBANILIDE
• 1-(4-CHLOROPHENYL)-3-PHENYL-2-THIOUREA
• 1-PHENYL-3-(2-THIAZOLYL)-2-THIOUREA
• Di-o-tolythiourea
• 3-(TRIFLUOROMETHYL)PHENYLTHIOUREA
• 2,4-DIFLUOROPHENYLTHIOUREA
• 1-[2-(METHYLTHIO)PHENYL]-2-THIOUREA
• N-(2-Methylphenyl)thiourea
• Diafenthiuron
• 1-(alpha-Phenethyl)-3-phenyl-2-thiourea,1-(BETA-PHENETHYL)-3-PHENYL-2-THIOUREA,1-(B-PHENETHYL)-3-PHENYL-2-THIOUREA