5-AMINO-4-FLUORO-2-METHYLPHENOL Chemical Properties

Melting point:

147 °C

Boiling point:

271.0±35.0 °C(Predicted)

Density 

1.275±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

form 

crystalline powder

pka

10.39±0.23(Predicted)

color 

Reddish light brown

Safety Information

Hazard Codes 

Xi

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36/37/39

Hazard Note 

Irritant

HS Code 

2922290090

5-AMINO-4-FLUORO-2-METHYLPHENOL Usage And Synthesis

Synthesis

General procedure: a mixture of 4-fluoro-2-methyl-5-nitrophenol (1.4 g, 8.2 mmol) and 10% Pd/C (0.3 g, 20% w/w) in methanol (80 mL) was stirred for 2 hours under hydrogen atmosphere (30 psi). Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was concentrated to afford 5-amino-4-fluoro-2-methylphenol (0.68 g, 62% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.75 (s, 1H), 6.62 (d, J = 12.0 Hz, 1H), 6.21 (d, J = 8.1 Hz, 1H), 4.69 (s, 2H), 1.93 (s, 3H).

References

[1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 69-70
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5369 - 5389
[3] Patent: US6362336, 2002, B1. Location in patent: Example 13

5-AMINO-4-FLUORO-2-METHYLPHENOL(122455-85-0)Related Product Information

• 5-AMINO-4-FLUORO-2-METHYLPHENOL SULFATE
• 5-((7-BENZYLOXYQUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL HYDROCHLORIDE
• 5-((7-(BENZYLOXY)QUINAZOLIN-4-YL)AMINO)-4-FLUORO-2-METHYLPHENOL
• 4-FLUORO-6-METHYL-3-NITROPHENOL
• 3-Amino-4-fluorophenol
• 5-AMINO-4-FLUORO-2-METHYLPHENOL