1,2-Bis(2-chloroethoxy)ethane Chemical Properties

Melting point:

-31°C

Boiling point:

235 °C(lit.)

Density 

1.197 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.461(lit.)

Flash point:

250 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

insoluble

form 

clear liquid

color 

Colorless to Almost colorless

Water Solubility 

insoluble

BRN 

506177

InChI

InChI=1S/C6H12Cl2O2/c7-1-3-9-5-6-10-4-2-8/h1-6H2

InChIKey

AGYUOJIYYGGHKV-UHFFFAOYSA-N

SMILES

C(OCCCl)COCCCl

CAS DataBase Reference

112-26-5(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, 1,2-bis(2-chloroethoxy)-(112-26-5)

EPA Substance Registry System

1,2-Bis(2-chloroethoxy)ethane (112-26-5)

Safety Information

Hazard Codes 

Xn

Risk Statements 

19-21/22-37/38-41-36/37/38

Safety Statements 

26-36/37/39

RIDADR 

UN 2810 6.1/PG 3

WGK Germany 

3

RTECS 

KH4900000

TSCA 

TSCA listed

HazardClass 

6.1

PackingGroup 

III

HS Code 

29091900

Storage Class

6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects

Hazard Classifications

Acute Tox. 3 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3

Hazardous Substances Data

112-26-5(Hazardous Substances Data)

MSDS

• Language:English Provider:1,2-Bis(2-chloroethoxy)ethane
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,2-Bis(2-chloroethoxy)ethane Usage And Synthesis

Chemical Properties

clear colorless to pale yellow liquid. Insoluble in water. Combustible.

Uses

Solvent for hydrocarbons, oils, etc.; extractant; intermediate for resins and insecticides; organic synthesis.

Uses

1,2-Bis(2-chloroethoxy)ethane is used as pharmaceutical intermediate.

Uses

1,2-bis(2-chloroethoxy)ethane was used in the synthesis of 1,1′-[1,2-ethanediylbis(oxy-1,2-ethanediyl)]bis[3-methyl-1H-imidazolium-1-yl] chloride.

Synthesis

Triethylene glycol (0.28 mol) and pyridine (49 mL, 0.61 mol) were mixed in benzene (250 mL) in a dry reaction flask and the resulting reaction mixture was heated to reflux. Dichlorosulfoxide (0.61 mole) was added to the reaction mixture slowly and dropwise for about 3 hours. At the end of the addition the reaction mixture was kept at reflux and stirred for 16 hours. At the end of the reaction the resulting reaction mixture was cooled to room temperature and hydrochloric acid (6.3 mL, 11.8 M) diluted in diluted water (50 mL) was slowly added dropwise to the above reaction mixture for about 15 minutes. The upper benzene solution in the reaction mixture was separated and concentrated under reduced pressure to evaporate the benzene solution and the resulting residue was the target product molecule 1,2-bis(2-chloroethoxy)ethane.

1,2-Bis(2-chloroethoxy)ethane(112-26-5)Related Product Information

• Triethylene glycol
• Diethylene glycol
• Dipropylene glycol
• Hexafluoroethane
• Triethylene glycol bis(2-ethylhexanoate)
• 2,2'-Dichlorodiethyl ether
• 2-Butoxyethanol
• PENTACHLOROETHANE
• 2-Methyl-2,4-pentanediol
• Dichloroethane
• TRIETHYLENE GLYCOL MONOMETHYL ETHER
• DIETHOXYMETHANE
• ETHANE
• Sodium dichloroisocyanurate
• CHLOROETHANE
• 1,4-Butanediol
• Thionyl chloride
• Diethyl ether