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3-Amino-5-fluoropyridine

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3-Amino-5-fluoropyridine Basic information

Product Name:
3-Amino-5-fluoropyridine
Synonyms:
  • 3-AMINO-5-FLUOROPYRIDINE
  • 3-Pyridinamine,5-fluoro-(9CI)
  • 3-AMINO-5-FLUOROPYRIDINE 97%
  • 5-Fluoropyridin-3-amine
  • 5-Fluoropyridin-3-ylamine
  • 3-Amine-5-fluoro-pyridin
  • 3-AMine-5-fluoro-pyridine
  • 3-PyridinaMine,5-fluoro-
CAS:
210169-05-4
MF:
C5H5FN2
MW:
112.11
EINECS:
664-255-5
Product Categories:
  • Fluorine series
  • Building Blocks
  • C5
  • C5 to C6
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • PYRIDINE
  • Pyridine series
  • Pyridines
  • Boronic Acid
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Heterocyclic Fluorinated Building Blocks
  • Other Fluorinated Heterocycles
  • AMINEPRIMARY
  • HALIDE
Mol File:
210169-05-4.mol
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3-Amino-5-fluoropyridine Chemical Properties

Melting point:
86°C
Boiling point:
232.7±20.0 °C(Predicted)
Density 
1.257±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
form 
powder to crystal
pka
3.74±0.20(Predicted)
color 
Light orange to Yellow to Green
CAS DataBase Reference
210169-05-4(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
20/21/22-36/37/38-22
Safety Statements 
26-36-36/37
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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3-Amino-5-fluoropyridine Usage And Synthesis

Chemical Properties

Light yellow Crystal

Uses

3-amino-5-fluoropyridine is an important intermediate mainly used in medicine and organic synthesis. It is used to synthesize Ivosidenib. Ivosidenib is an isocitrate dehydrogenase-1 inhibitor used to treat acute myeloid leukemia and cholangiocarcinoma in adults.

Application

Reactant for:
Preparation of nonpeptide inhibitors of measles virus entry.

Preparation

synthesis of 3-Amino-5-fluoropyridine: A solution of 3-amino-2,4,6-tribromo-5-fluoropyridine (23c) (0.9 g, 2.6 mmol), triethylamine (1.1 cm3, 7.9 mmol), palladium catalyst (0.1 g of 5% Pd-C catalyst) and DCM (15 cm3) was hydrogenated on a Parr apparatus for 18 h. Water (20 cm3) was added and the mixture filtered and extracted into DCM. The DCM solution was dried (MgS04) and evaporated giving 3-amino-5-fluoropyridine (0.3 g, >95% ), m.p. 86 ·c (from DCM) (Found: C, 53.6; H, 4.6; N, 25.0. C5H5FN2 requires C, 53.6; H, 4.5 N, 25.0%);
IR spectrum no. 9; mass spectrum no. 5; nmr spectrum no. 29.

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