Basic information Safety Supplier Related

ACPT-I

Basic information Safety Supplier Related

ACPT-I Basic information

Product Name:
ACPT-I
Synonyms:
  • ACPT-I
  • 4-AMINO-1BETA,2BETA,4BETA-CYCLOPENTANETRICARBOXYLIC ACID
  • (1S,3R,4S)-1-AMINOCYCLOPENTANE-1,3,4-TRICARBOXYLIC ACID
  • 1,2,4-Cyclopentanetricarboxylic acid, 4-amino-, (1α,2α,4β)-
  • ACPT I,ACPTI
CAS:
194918-76-8
MF:
C8H11NO6
MW:
217.18
Mol File:
194918-76-8.mol
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ACPT-I Chemical Properties

Boiling point:
440.4±45.0 °C(Predicted)
Density 
1.651±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at -20°C
solubility 
Soluble to 10 mM in water and to 50 mM in 1.1eq. NaOH
form 
Powder
pka
1.85±0.60(Predicted)
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ACPT-I Usage And Synthesis

Description

ACPT-I is an agonist of the group III metabotropic glutamate receptors (mGluRs) mGluR4a and mGluR8 (EC50s = 7.2 and 8.2 μM, respectively) that has no effect on mGluR1a or mGluR2. It has diverse biological activity, including neuroprotective, anticonvulsant, and anxiolytic-like effects. ACPT-I (1-200 μM) reduces cell death following oxygen-glucose deprivation in primary neuronal cultures and in a rat model of middle cerebral artery occlusion when used at a dose of 30 mg/kg. It is neuroprotective against excitotoxicity induced by kainite in vitro and in vivo and reduces the incidence of clonic seizures in various seizure models in mice and rats (ED50s = 0.08-49.3 nM, i.c.v.). ACPT-I also has anxiolytic-like effects in mice and rats, however, these effects can be blocked by WAY-100635 and flumazenil , indicating the involvement of the serotonin (5-HT) receptor subtype 5-HT1A and GABAA receptor.

Uses

ACPT-I is a competitive antagonist for metabotropic receptors (mGluRs).

Biological Activity

Agonist for group III mGlu receptors (EC 50 values are 7.2 and 8.2 μ M for mGlu 4a and mGlu 8 respectively). Anticonvulsant in mice.

storage

Desiccate at -20°C

ACPT-ISupplier

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
EMMX Biotechnology LLC
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888-539-0666
Email
info@emmx.com
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Email
info@efebio.com
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com