Hydroxymetronidazole Chemical Properties

Melting point:

118-121°C

Boiling point:

321.89°C (rough estimate)

Density 

1.4796 (rough estimate)

refractive index 

1.5800 (estimate)

storage temp. 

-20°C Freezer

solubility 

DMSO (Sparingly), Methanol (Slightly)

pka

13.28±0.10(Predicted)

color 

White to Light Beige

Safety Information

Safety Statements 

24/25

WGK Germany 

3

RTECS 

NI5568000

HS Code 

29332900

Hydroxymetronidazole Usage And Synthesis

Description

Hydroxy metronidazole is a metabolite of metronidazole. Metronidazole belongs to the nitroimidazole class of drugs. In agricultural production, it is often used as a drug to expel parasites in animals. After being added to animal feed, metronidazole remains in eggs. Because metronidazole has a variety of toxic and side effects on the human body, especially its potential carcinogenicity and hereditary mutation effects, and metronidazole can be rapidly distributed throughout the body after entering the human body, so the residual metronidazole and its metabolites in eggs inspection is necessary.

Chemical Properties

Off-White Solid

Uses

Hydroxymetronidazole (Metronidazole-OH) is a metabolite of Metronidazole belonging to the class of nitroimidazoles. Hydroxymetronidazole can be used for the research of certain bacterial and protozoal diseases in poultry, swine dysentery and genital trichomoniasis in cattle.

Definition

ChEBI: Metronidazole-OH is a member of imidazoles and a C-nitro compound.

Biological Activity

Hydroxymetronidazole is an active metabolite of the antibiotic metronidazole (Item No. 9002409). It is formed from metronidazole primarily by the cytochrome P450 (CYP) isoform CYP2A6. Hydroxymetronidazole is active against B. fragilis, B. thetaiotaomicron, B. distasonis, and B. ovatus (MICs = 1, 2, 1, and 2 μg/ml, respectively). It has been found in pork and porcine plasma.

Hydroxymetronidazole(4812-40-2)Related Product Information

• 4'-Hydroxyacetophenone
• 2-(1-METHYL-5-NITRO-1H-IMIDAZOL-2-YL)-PROPAN-2-OL
• Metronidazole Impurity 10
• Pyraclostrobin
• Glyphosate
• 1-[[(2S,3S)-3-(2-Chlorophenyl)-2-(4-fluorophenyl)oxiran-2-yl]methyl]-1,2,4-triazole
• Pyrimethanil
• Fenvalerate
• Diniconazole
• Imidazole
• Cyprodinil
• alpha,2-Dimethyl-5-nitro-1H-imidazole-1-ethanol
• 1-Methyl-5-nitro-1H-imidazole-2-methanol
• Metronidazole
• Hydroxymetronidazole
• 1-(2-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE(METRONIDAZOLE-OH MNZOH)
• 1-(2-HYDROXYETHYL)-2-HYDROXYMETHYL-5-NITROIMIDAZOLE (HYDROXYMETRONIDAZOLE)