1-CYCLOHEXYLPIPERIDINE Chemical Properties

Melting point:

73-74 °C(Solv: benzene (71-43-2); ligroine (8032-32-4)(1:5))

Boiling point:

231-234°C

Density 

0,914 g/cm³

refractive index 

1.4856

Flash point:

231-234°C

pka

10.07±0.20(Predicted)

form 

clear liquid

color 

Colorless to Light yellow

Water Solubility 

Immiscible with water.

BRN 

105594

Safety Information

Risk Statements 

36/38

Safety Statements 

26-36

RTECS 

TM6520000

HS Code 

2933.39.9200

Toxicity

mouse,LD50,intravenous,32mg/kg (32mg/kg),U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02603,

MSDS

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1-CYCLOHEXYLPIPERIDINE Usage And Synthesis

Uses

1-Cyclohexylpiperidine is used in the preparation of 1-(1-phenylcyclohexyl)piperidine, which shows anticholinesterase activity and antagonistic activity to acetylcholine. It is used as a N-methyl-D-aspartate receptor (NMDAR) antagonist. Further, it is used as an anesthetic for animals.

Definition

ChEBI: N-cyclohexylpiperidine is a member of piperidines.

Synthesis Reference(s)

Journal of the American Chemical Society, 72, p. 1597, 1950 DOI: 10.1021/ja01160a046
Tetrahedron, 52, p. 10835, 1996 DOI: 10.1016/0040-4020(96)00631-X

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