DBCO-PEG1 Chemical Properties

Boiling point:

716.8±60.0 °C(Predicted)

Density 

1.30±0.1 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

14.45±0.10(Predicted)

DBCO-PEG1 Usage And Synthesis

Description

DBCO-C2-alcohol is a linker containing a DBCO moiety and a terminal primary hydroxyl group. DBCO group can react with azides in copper-free Click Chemistry reactions. The hydroxyl can react with a variety of functional groups.

Uses

DBCO-PEG1 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG1 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

DBCO-PEG1(1839049-33-0)Related Product Information

• DBCO-Acid
• DBCO-NH-Boc
• Cy3 DBCO
• DBCO-maleimide
• Dbco-Amine TFA
• Cy5 DBCO
• Azadibenzocyclooctyne-Biotin conjugate
• Oleic-DBCO
• DBCO-C-PEG1
• DBCO-C6-acid
• BDP FL DBCO
• DBCO-(CH2)2-NH2-CO-(CH2)2COOH
• DBCO-amine
• DBCO-NHS Ester
• DBCO-(CH2)2-NH2-CO-(CH2)3COOH
• DBCO-(CH2)3-Acid
• DBCO-PEG4-triethoxysilane
• Propanoic acid, 3-[2-[2-[[4-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1,4-dioxobutyl]amino]ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester