(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER Chemical Properties

Boiling point:

350.89°C (rough estimate)

Density 

1.2545 (rough estimate)

refractive index 

1.5150 (estimate)

storage temp. 

2-8°C

form 

solid

pka

9.67±0.20(Predicted)

color 

White

Safety Information

HS Code 

2922500090

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER Usage And Synthesis

Description

CHF-1301 was launched as an injection in Italy for the treatment of patients with Parkinson's disease, particularly those with complications in their clinical responses. CHF-1301 is the methyl ester of L-Dopa (levodopa), the immediate precursor of dopamine. Thus, this prodrug is more soluble in water at physiological pH, better absorbed and slowly transformed into levodopa in vivo; it consequently improves the duration of action and prevents the rapid fluctuations in response or involontary movements (dyskinesia) observed during chronic treatment with levodopa. In patients with a delayed effect of levodopa (on-phenomenon) or a severe resistance to L-Dopa (off-phenomenon), CHF- 1301 significantly improves the onset and the stability of the'response.

Originator

Chiesi Farmaceutici SpA (Italy)

Definition

ChEBI: Melevodopa is a tyrosine derivative.

brand name

Levomet

(S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER(7101-51-1)Related Product Information

• Ethyl methyldopate hydrochloride
• Benzyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
• Levodopa
• L-3,4-DIHYDROXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
• (S)-3,4-DIMETHOXYPHENYLALANINE METHYL ESTER HYDROCHLORIDE
• (S)-2-AMINO-3-(3,4-DIHYDROXY-PHENYL)-PROPIONIC ACID METHYL ESTER
• METHYL (2S)-2-AMINO-3-(3-HYDROXY-4-METHOXYPHENYL)PROPANOATE
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• METHYL (2S)-2-AMINO-3-(3,4,5-TRIMETHOXYPHENYL)PROPANOATE
• (S)-6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-3-ISOQUINOLINE CARBOXYLIC TERT BUTYL ESTER
• METHYL (2S)-2-AMINO-3-[4-METHOXY-3-(PHENYLMETHOXY)PHENYL]PROPANOATE
• METHYL (2S)-2-AMINO-3-(5-BROMO-3,4-DIMETHOXYPHENYL)PROPANOATE
• METHYL 3-(2H-BENZO[3,4-D]1,3-DIOXOLEN-5-YL)(2S)-2-AMINOPROPANOATE
• 3-O-METHYL-4-O-BOC-6-TRIMETHYLSTANNYL-L-DOPA
• METHYLDOPA METHYL ESTER
• METHYL (2S)-2-AMINO-3-(2-BROMO-4,5-DIMETHOXYPHENYL)PROPANOATE
• L-TYROSINE, 5-[[(1,1-DIMETHYLETHOXY)CARBONYL]OXY]-N-[(1,1-DIMETHYLETHOXY)CARBONYL]-2-(TRIMETHYLSTANNYL)-, METHYL ESTER, 1,1-DIMETHYLETHYL CARBONATE
• N-BENZOYL-2-HYDROXY-4,5-DIMETHOXYPHENYLALANINE ETHYL ESTER