1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Basic information
- Product Name:
- 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- Synonyms:
-
- 1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester
- tert-butyl 4-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperazine-1-carboxylate
- Thalidomide-piperazine-Boc
- Thalidomide-5-piperazine-Boc
- CAS:
- 2222114-64-7
- MF:
- C22H26N4O6
- MW:
- 442.46
- Product Categories:
-
- chem-chemical
- Mol File:
- 2222114-64-7.mol
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Chemical Properties
- Boiling point:
- 674.6±55.0 °C(Predicted)
- Density
- 1.373±0.06 g/cm3(Predicted)
- solubility
- DMSO : 41.67 mg/mL (94.18 mM; Need ultrasonic)
- pka
- 10.83±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester Usage And Synthesis
Biological Activity
Thalidomide-piperazine-Boc is an intermediate that can be used in the synthesis of B-cell lymphoma 6 protein (BCL6) PROTAC[1].
References
[1]. Michael Berlin, et al. Bifunctional molecules containing an e3 ubiquitine ligase binding moiety linked to a bcl6 targeting moiety. WO2021077010A1.
1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl esterSupplier
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1-Piperazinecarboxylic acid, 4-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]-, 1,1-dimethylethyl ester(2222114-64-7)Related Product Information
- 1-Piperidinecarboxylic acid, 3-(4-hydroxyphenyl)-2,6-dioxo-, 1,1-dimethylethyl ester
- Tert-butyl 4-(4-aMino-3-Methoxyphenyl)piperazine-1-carboxylate
- tert-butyl (S)-3-(cyanomethyl)piperazine-1-carboxylate
- 1-Piperidinecarboxylic acid, 3-(4-amino-1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-2,6-dioxo-, 1,1-dimethylethyl ester
- tert-Butyl 2,6-dioxo-3-(4-(prop-2-yn-1-yloxy)phenyl)piperidine-1-carboxylate