4-Methyl-2-nitrobenzaldehyde Chemical Properties

Boiling point:

309.4±30.0 °C(Predicted)

Density 

1.278±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

Appearance

Light yellow to yellow Solid

InChI

InChI=1S/C8H7NO3/c1-6-2-3-7(5-10)8(4-6)9(11)12/h2-5H,1H3

InChIKey

FDYADQPZUDULNK-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(C)C=C1[N+]([O-])=O

Safety Information

HS Code 

2913000090

4-Methyl-2-nitrobenzaldehyde Usage And Synthesis

Synthesis

General procedure for the synthesis of 4-methyl-2-nitrobenzaldehyde from (4-methyl-2-nitrophenyl)methanol: (4-methyl-2-nitrophenyl)methanol (1.028 g, 6.15 mmol), pyridinium dichromate (3.47 g, 9.22 mmol), and molecular sieves (7 g, 6.15 mmol) were dissolved in anhydrous dichloromethane (14 mL) under argon protection and stirred at room temperature overnight. The reaction mixture was filtered through a silica/diatomaceous earth (1:1) column and subsequently extracted with water and dichloromethane. The organic layers were combined and the solvents were evaporated to give a light yellow solid product (0.665 g, 65.5% yield), which could be used in subsequent reactions without further purification. The product was characterized by 1H-NMR (CDCl3): δ 2.54 (s, 3H), 7.57-7.60 (m, 1H), 7.86-7.90 (m, 2H), 10.49 (s, 1H). the LC/MS analysis showed a retention time of 3.01 min (100% purity, no ionization peaks observed).

References

[1] Monatshefte fur Chemie, 1998, vol. 129, # 12, p. 1305 - 1308
[2] Synthetic Communications, 1999, vol. 29, # 2, p. 163 - 166
[3] RSC Advances, 2016, vol. 6, # 56, p. 51347 - 51355
[4] Patent: WO2009/37294, 2009, A1. Location in patent: Page/Page column 142

4-Methyl-2-nitrobenzaldehyde(20357-22-6)Related Product Information

• METSULFURON METHYL
• Bensulfuron methyl
• Methyl acetate
• Kresoxim-methyl
• 2-Methylbenzaldehyde
• 3-(Trifluoromethyl)benzaldehyde
• 2-(Trifluoromethyl)benzaldehyde
• Methylparaben
• Methyl acrylate
• 4-Nitrobenzaldehyde
• p-Tolualdehyde
• 2-Nitrobenzaldehyde
• Thiophanate-methyl
• Methyl
• Methyl bromide
• Dimethyl nitroterephthalate
• nitrotoluene
• 2-NITRO-3-ACETYLAMINO-4-METHYLBENZOIC ACID