Basic information Safety Supplier Related

5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE

Basic information Safety Supplier Related

5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE Basic information

Product Name:
5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE
Synonyms:
  • 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE
  • 5-METHOXY-4-AZAINDOLE
  • 5-Methoxypyrrolo[3,2-b]pyridine
  • 5-Methoxy-4-azaindole,5-Methoxy-1H-pyrrolo[3,2-b]pyridine
  • 1H-Pyrrolo[3,2-b]pyridine, 5-Methoxy-
  • 5-Metho×y-4-azaindole,5-Metho×y-1H-pyrrolo[3,2-b]pyridine
  • 5-Methoxy-1H-pyrrolo[3
  • 5-Methoxy-1H-pyrrolo[3,2-b]pyridine 97%
CAS:
17288-40-3
MF:
C8H8N2O
MW:
148.16
Product Categories:
  • Heterocycle-Pyridine series
Mol File:
17288-40-3.mol
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5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE Chemical Properties

Melting point:
115-116°C
Boiling point:
285℃
Density 
1.244
Flash point:
98℃
storage temp. 
2-8°C
form 
solid
pka
14.36±0.40(Predicted)
color 
Light yellow to brown
InChI
InChI=1S/C8H8N2O/c1-11-8-3-2-6-7(10-8)4-5-9-6/h2-5,9H,1H3
InChIKey
WTIFEVSWZUSXQL-UHFFFAOYSA-N
SMILES
C12C=CNC1=CC=C(OC)N=2
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
22-41
Safety Statements 
26-39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
2933399990
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5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE Usage And Synthesis

Synthesis

111795-99-4

17288-40-3

GENERAL METHOD: 6-methoxy-3-nitropyridine-2-acetonitrile derivative 13a or 13b (12.9 mmol) was dissolved in ethanol or methanol (40 mL) and a catalytic amount of 10% palladium carbon was added. The reaction mixture was placed in a Paar hydrogenation unit and hydrogenated at room temperature for 24 hours. Upon completion of the reaction, the catalyst was removed by filtration and the solvent was removed by concentration under reduced pressure. The resulting residue was purified by column chromatography with the eluent dichloromethane/ethyl acetate (95/5 for compound 14a) or (6/4 for compound 14b).

References

[1] Heterocycles, 1999, vol. 50, # 2, p. 1065 - 1080
[2] Current Medicinal Chemistry, 2014, vol. 21, # 14, p. 1654 - 1666
[3] Liebigs Annalen der Chemie, 1988, p. 203 - 208
[4] European Journal of Medicinal Chemistry, 2004, vol. 39, # 6, p. 515 - 526
[5] Patent: US2009/298820, 2009, A1. Location in patent: Page/Page column 36

5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINESupplier

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