3-Hydroxypyridine Chemical Properties

Melting point:

125-128 °C (lit.)

Boiling point:

280-281 °C(lit.)

Density 

1.1418 (rough estimate)

refractive index 

1.5939 (estimate)

Flash point:

173°C

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

33g/l

form 

Crystalline Powder

pka

4.79, 8.75(at 20℃)

color 

Beige to brown

PH

6.0-6.5 (33g/l, H2O, 20℃)

Water Solubility 

32.26g/L(20 ºC)

BRN 

105699

LogP

0.480

CAS DataBase Reference

109-00-2(CAS DataBase Reference)

NIST Chemistry Reference

3-Pyridinol(109-00-2)

EPA Substance Registry System

3-Pyridinol (109-00-2)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-40

Safety Statements 

26-36-37/39-22

WGK Germany 

3

RTECS 

UV1144050

F 

8

Hazard Note 

Irritant

TSCA 

Yes

HS Code 

29333999

MSDS

• Language:English Provider:3-Pyridinol
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

3-Hydroxypyridine Usage And Synthesis

Chemical Properties

white to light yellow crystal. Soluble in alcohol and water, slightly soluble in ether and benzene. It becomes a red solution when it encounters ferric chloride, and it is easy to decompose in the air.

Uses

3-Hydroxypyridine (cas# 109-00-2) is a compound useful in organic synthesis.

Preparation

3-hydroxypyridine was prepared by reacting furfurylamine with H2O2 in the presence of HCl, followed by hydrolysis. The optimal conditions were found as fellows: molar ratio of furfurylamine: HCl : H2O2 = 1 : 5 : 1.1, and H2O2 added dropwisely at 0-5 °C, and then refluxed at 100-105 °C for 0.5 h.

Definition

ChEBI: 3-Hydroxypyridine is a monohydroxypyridine that is pyridine in which the hydrogen at position 3 has been replaced by a hydroxy group. It has been detected as a thermal degradation product from the smoke of the burning leaves of Salvia divinorum, a Mexican psychoactive plant.

brand name

Ventavis (Schering).

Purification Methods

Crystallise 3-hydroxypyridine from *C6H6, water or EtOH. [Beilstein 21 III/IV 402, 21/2 V 68.]

3-Hydroxypyridine(109-00-2)Related Product Information

• 3-Aminopyridine
• 2-Amino-3-hydroxypyridine
• 4-Hydroxypyridine
• Sulfasalazine
• Chromium picolinate
• 2-Chloro-3-hydroxypyridine
• 2-Chloro-3-cyanopyridine
• Hydroxy silicone oil
• 2-Bromo-3-hydroxypyridine
• Dimethoxymethylphenylsilane
• Acetamide
• ETHYL 2-CHLOROPYRIMIDINE-4-CARBOXYLATE
• Genistein
• Germanium
• 3-Hydroxy-2-methylpyridine
• 3-Hydroxypicolinic acid
• a-Hydroxypyridine
• 2-Amino-3-benzyloxypyridine