Chloromethyl ethyl ether Chemical Properties

Melting point:

-104°C

Boiling point:

82 °C(lit.)

Density 

1.019 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.404(lit.)

Flash point:

67 °F

storage temp. 

0-6°C

solubility 

Chloroform (Soluble), Ethyl Acetate (Slightly)

form 

Liquid

Specific Gravity

1.019

color 

Clear colorless to pale yellow

InChI

InChI=1S/C3H7ClO/c1-2-5-3-4/h2-3H2,1H3

InChIKey

FCYRSDMGOLYDHL-UHFFFAOYSA-N

SMILES

CCOCCl

CAS DataBase Reference

3188-13-4(CAS DataBase Reference)

NIST Chemistry Reference

Ethane, (chloromethoxy)-(3188-13-4)

EPA Substance Registry System

Ethane, (chloromethoxy)- (3188-13-4)

Safety Information

Hazard Codes 

F,Xn

Risk Statements 

11-20/21/22-36-40

Safety Statements 

16-36/37-9-45-29

RIDADR 

UN 2354 3/PG 2

WGK Germany 

3

HazardClass 

6.1(a)

PackingGroup 

I

HS Code 

29091990

Hazardous Substances Data

3188-13-4(Hazardous Substances Data)

MSDS

• Language:English Provider:Chloromethyl ethyl ether
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

Chloromethyl ethyl ether Usage And Synthesis

Chemical Properties

clear colorless to pale yellow liquid

Uses

Chloromethyl ethyl ether can be used to prepare:

• 6-Benzyl-1-(ethoxymethyl)-5-iodopyrimidine-2,4(1H,3H)-dione, a key intermediate in the preparation of MKC-442 analog.
• Acylation catalyst for alcohols named 1,3-bis-[(R)-1-(2-naphthyl)ethyl]imidazoliumchloride by reacting with glyoxal-bis-[(R)-1-(2-naphthyl)ethyl]imine.

General Description

A colorless liquid. Slightly denser than water and insoluble in water. Flash point below 73°F. May be moderately toxic by ingestion, inhalation or skin absorption. Severely irritates skin, eyes and mucous membranes.

Air & Water Reactions

Highly flammable. Insoluble in water.

Reactivity Profile

Chloromethyl ethyl ether tends to form unstable peroxides when exposed to oxygen or air. These products can sometimes be observed as clear crystals deposited on containers or along the surface of the liquid. Forms salts with strong acids and addition complexes with Lewis acids. May react violently with strong oxidizing agents. I

Health Hazard

TOXIC; may be fatal if inhaled, ingested or absorbed through skin. Inhalation or contact with some of these materials will irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion and poison hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Chloromethyl ethyl ether(3188-13-4)Related Product Information

• 2-Methoxyethoxymethyl chloride
• Isobutyl chloroformate
• Benzyl chloroformate
• (-)-MENTHYL CHLOROFORMATE
• Propyl chloroformate
• 2,2,2-Trichloroethyl chloroformate
• 2,2,2-TRICHLORO-1,1-DIMETHYLETHYL CHLOROFORMATE
• (+/-)-1,2,2,2-TETRACHLOROETHYL CHLOROFORMATE
• 1-CHLORO-2-METHYLPROPYL CHLOROFORMATE
• 2-BROMOETHYL CHLOROFORMATE
• 9-Fluorenylmethyl chloroformate
• Allyl chloroformate
• Cholesteryl chloroformate
• 3-Chlorophthalide
• Ethyl chloroformate
• CHLOROMETHYL OCTYL ETHER
• CHLOROFORMIC ACID N-OCTYL ESTER
• 2-(Trimethylsilyl)ethoxymethyl chloride
• Ethoxymethyl Chloride