N-Methyl-(5-bromopyrid-3-yl)methylamine Chemical Properties

Boiling point:

125 °C

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

Safety Information

Hazard Codes 

C

Hazard Note 

Corrosive

HS Code 

2933599590

N-Methyl-(5-bromopyrid-3-yl)methylamine Usage And Synthesis

Synthesis

GENERAL STEPS: 1.8 g (27 mmol) of methylamine hydrochloride and 0.4 g (6 mmol) of sodium cyanoborohydride were added sequentially to a 20 mL methanol solution containing 1 g (5.4 mmol) of 5-bromopyridine-3-carbaldehyde. The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the precipitate was removed by filtration and the filtrate was concentrated to dryness under reduced pressure. The residue was dissolved in dichloromethane and washed with deionized water. After separating the organic phase, the organic phase was washed with dilute aqueous hydrochloric acid. The acid-washed aqueous phase was adjusted to pH 9 with aqueous sodium hydroxide and subsequently extracted with dichloromethane. The organic phases were combined, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with dichloromethane/methanol (9.5:0.5, v/v) as eluent. 0.5 g (50% yield) of N-methyl-(5-bromopyridin-3-yl)methylamine was finally obtained.

References

[1] Patent: WO2004/113331, 2004, A1. Location in patent: Page 44-45

N-Methyl-(5-bromopyrid-3-yl)methylamine(73335-64-5)Related Product Information

• 5-BROMO-N-TERT-BUTYLNICOTINAMIDE
• (5-BROMOPYRIDIN-3-YL)-MORPHOLIN-4-YL-METHANONE
• 5-BROMO-N,N-DIMETHYL-3-PYRIDINECARBOXAMIDE
• 5-BROMO-N,N-DIETHYL-3-PYRIDINECARBOXAMIDE
• 1-(5-BROMO-PYRIDINE-3-CARBONYL)-PYRROLIDINE-2-CARBOXYLIC ACID
• 5-BROMO-3-(PIPERIDIN-1-YLCARBONYL)PYRIDINE
• TCV 309
• N-Benzyl-5-bromo-nicotinamide
• 5-Bromo-N-methyl-nicotinamide
• 5-bromo-N-(2-bromo-4-methylphenyl)pyridine-3-carboxamide
• AURORA 22740
• 4-[(5-bromopyridin-3-yl)formamido]butanoic acid
• AURORA 1932
• AURORA 22741
• AURORA 22743
• 5-bromo-N-(4-bromophenyl)pyridine-3-carboxamide
• AURORA 10464
• AURORA 22739