Masoprocol
Masoprocol Basic information
- Product Name:
- Masoprocol
- Synonyms:
-
- masoprocol
- 4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol
- (R*,S*)-4,4'-(2,3-dimethylbutane-1,4-diyl)bispyrocatechol
- Masoprocol(nordihydroguaiaretic)
- NORHYDROGUAIARETICACID
- CHX-100
- meso-4,4'-(2,3- Dimethyltetramethylene)dipyrocatechol
- 4-[(2S,3R)-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]benzene-1,2-diol
- CAS:
- 27686-84-6
- MF:
- C18H22O4
- MW:
- 302.36
- EINECS:
- 248-606-6
- Mol File:
- 27686-84-6.mol
Masoprocol Chemical Properties
- Melting point:
- 185.5°C
- Boiling point:
- 526.5±45.0 °C(Predicted)
- Density
- 1.241±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 9.56±0.10(Predicted)
- form
- Solid
- color
- Off-white to light yellow
- LogP
- 3.710 (est)
- EPA Substance Registry System
- 1,2-Benzenediol, 4,4'-(2,3-dimethyl-1,4-butanediyl)bis-, (R*,S*)- (27686-84-6)
Masoprocol Usage And Synthesis
Description
Masoprocol is a lipoxygenase inhibitor launched as a topical agent for the treatment of solar or actinic keratoses. It is the first new topical treatment for pre-malignant skin lesions introduced in twenty years. Masoprocol is obtained from the Larrea tridentata plant and is also under investigation for the treatment of lung, breast, colon and ovarian cancers.
Originator
Chemex (U.S.A.)
Uses
Antineoplastic.
Definition
ChEBI: Masoprocol is the meso-form of nordihydroguaiaretic acid. An antioxidant found in the creosote bush, Larrea divaricata, it is a potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. It also inhibits (though to a lesser extent) formyltetrahydrofolate synthetase, carboxylesterase, and cyclooxygenase. It has a role as an antineoplastic agent, a lipoxygenase inhibitor, a hypoglycemic agent and a metabolite.
brand name
Actinex (University Of Arizonia Cancer Center).
Masoprocol Preparation Products And Raw materials
Raw materials
MasoprocolSupplier
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