Alcuronium Chloride
Alcuronium Chloride Basic information
- Product Name:
- Alcuronium Chloride
- Synonyms:
-
- Alcuronium
- Alcuronium dichloride
- N,N′-Diallylnortoxiferinium dichloride
- Alcuronium chloride CRS
- Alcuronium Chloride USP/EP/BP
- CAS:
- 15180-03-7
- MF:
- C44H50N4O2.2Cl
- MW:
- 737.811
- EINECS:
- 239-229-8
- Mol File:
- 15180-03-7.mol
Alcuronium Chloride Chemical Properties
- alpha
- D22 -348° (methanol)
Alcuronium Chloride Usage And Synthesis
Originator
Alloferin, Roche ,UK ,1966
Uses
Alcuronium Dichloride exists as a neuromuscular blocking agent with ganglion blocking activity. Binds to muscarinic M2 receptors.
Definition
ChEBI: Alcuronium chloride is chloride salt of alcuronium. It contains an alcuronium.
Manufacturing Process
31 g of diallylnortoxiferine diiodide are suspended in 1 liter of water and shaken with 1,100 ml of Amberlite IRA-400 [chloride ion form, described Merck Index, 7th edition, Merck and Co., Inc., Rahway, New Jersey (1960), page 1584], for 2 hours. The diiodide thereby goes into solution. The ion exchanger is filtered off and then washed in 3 portions with a total of 1 liter of water. The combined filtrates are then allowed to run through a column of 300 ml of Amberlite IRA-400 (chloride ion form), rinsed with 300 ml of water and the eluate evaporated to dryness in a vacuum while excluding air. The residue gives on recrystallization from methanol/ethanol crystalline pure colorless diallylnortoxiferine dichloride in a yield of 18.6 g. The compound contains 5 mols of water of crystallization after equilibration in air.
brand name
Alloferin (Hoffmann-LaRoche-International).
Therapeutic Function
Muscle relaxant