2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Chemical Properties

Density 

1.89±0.1 g/cm3(Predicted)

pka

5.90±0.20(Predicted)

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine Usage And Synthesis

Uses

2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is a pharmaceutical intermediate used in the preparation of Dipyridamole, an antiplatelet drug that is used primarily in the treatment of ischaemic heart disease and stroke. 2,4,6,8-Tetrahydroxy-Pyrimido(5,4-d)Pyrimidine is also used as a herbicide to control broadleaf weeds in wheat crops.

Synthesis

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4d)Pyrimidine is prepared by the reaction of 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid and urea. The specific synthesis steps are as follows:
5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid was charged into a two nicked flask, Urea (7.7 g, 128.0 mmol) was added dropwise with 125 ml of NaOH solution (500 g of sodium hydroxide + 1500 g of purified water) After dripping rapidly warming to 100 ° C,Insulation for one hour; continue to stir 3h,(25 ° C), filtered to obtain a solid, add purified water 250ml, heated to 60 ° C, heat lh, and then add dilute hydrochloric acid to ΡΗ = 4, cooled to room temperature filtration, washed and dried to obtain pyrimidine [5 , 4-d] pyrimidine-2,4,6,8-tetraol (tetrahydroxy), and recrystallized (ethanol solvent) to give 10.9 g in 86.9% yield.

2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine(6713-54-8)Related Product Information

• Diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate
• Dipyridamole Mono-O-b-D-glucuronide
• Dipyridamole
• 2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
• 2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE
• 2-[[2-[bis(2-hydroxyethyl)amino]-4,8-bis(2,2,3,3,4,4,5,5,6,6-decadeuteriopiperidin-1-yl)pyrimido[5,4-d]pyrimidin-6-yl]-(2-hydroxyethyl)amino]ethanol
• 2,2',2'',2'''-[[4-[(2-Hydroxyethyl)aMino]-8-(1-piperidinyl)pyriMido[5,4-d]pyriMidine-2,6-diyl]dinitrilo]tetrakisethanol (DipyridaMole IMpurity)
• Dipyridamole Tripiperidine
• Dipyridamole Tri(diethanolamine)
• 6-Des(diethanolamino)-6-chloro Dipyridamole
• 4,8-dichloro-2,6-dipiperidinopyrimido[5,4-d]pyrimidine
• Desethanol Dipyridamole
• Pyrimido[5,4-d]pyrimidin-4-ol (8CI)
• 2,4,6,8-Tetrahydroxy-Pyrimido-(5,4D)Pyrimidine