Safety Information

Hazardous Substances Data

77337-76-9(Hazardous Substances Data)

3-(acetylamino)propanesulphonic acid Usage And Synthesis

Originator

Campral,Merck

Uses

Treatment of alcohol dependency.

Definition

ChEBI: An organosulfonic acid that is propane-1-sulfonic acid substituted by an acetylamino group at position 3.

Manufacturing Process

In a 4 liter flask provided with stirring means, a bromine funnel and a thermometer, 17.5% sodium hydroxide solution and aminopropanesulfonic acid (homotaurine) are added.
After complete dissolution, at a temperature of between 25°-40°C, acetic anhydride are added so as not to exceed a temperature of between 30°-40°C. The mixture is then maintained at this temperature by heating for at least 1 h.
The solution is then concentrated in vacuum, the residue is redissolved in 2.5 L of distilled water and the mixture is concentrated again. The residue is then dissolved in 1.6 L of distilled water, filtered, then concentrated almost completely. Drying is terminated in an oven in vacuum. A colorless crystalline powder of 3-acetylaminopropanesulfonate of sodium (sodium Nacetylhomotaurinate) is obtained.
The 3-acetylaminopropanesulfonic acid may be produced by treatment of 3- acetylaminopropanesulfonate of sodium with hydrochloric acid.
In practice it is usually used as calcium salt.

brand name

Campral (Forest).

Therapeutic Function

Psychotropic

3-(acetylamino)propanesulphonic acid(77337-76-9)Related Product Information

• Calcium carbide
• RANAKININ
• Pentoxifylline
• Calcium stearate
• Potassium sorbate
• Organic acid
• Solvent
• N-(3-SULFOPROPYL)-SACCHARIN, SODIUM SALT
• Acamprosate calcium
• 3-(acetylamino)propanesulphonic acid
• Sulfo-NHS-Biotin
• Acamprosate-d3 Calcium
• Acamprosate Impurity 1 Potassium Salt
• 3-(Acetylmethylamino)-1-propanesulfonic Acid Calcium Salt
• Acamprosate Impurity B
• AMMONIUM SULFOBETAINE-3, 5% SOLUTION IN WATER
• AMMONIUM SULFOBETAINE-4, TECH., 85
• AMMONIUM SULFOBETAINE-2, TECH., 90