1-Pentyl-3-(1-naphthoyl)indole
1-Pentyl-3-(1-naphthoyl)indole Basic information
- Product Name:
- 1-Pentyl-3-(1-naphthoyl)indole
- Synonyms:
-
- 1-Pentyl-3-(1-naphthoyl)indole
- 1-Naphthyl-(1-pentylindol-3-yl)Methanone
- JWH-018 (Spice Cannabinoid)
- JWH 018 (solution)
- Naphthalen-1-yl-(1-pentylindol-3-yl)Methanone
- Naphthalen-1-yl(1-Pentyl-1H-Indol-3-yl)Methanone
- JWH -018
- 1-Naphthalenyl-(1-pentyl-1H-indol-3-yl)methanone
- CAS:
- 209414-07-3
- MF:
- C24H23NO
- MW:
- 341.45
- EINECS:
- 635-711-0
- Product Categories:
-
- Chemical for Research
- Research Chemical
- Aromatics
- Heterocycles
- Indole Derivatives
- Intermediates & Fine Chemicals
- Pharmaceuticals
- pharmaceutical intermediate and medicine grade
- intermediate
- Mol File:
- 209414-07-3.mol
1-Pentyl-3-(1-naphthoyl)indole Chemical Properties
- Melting point:
- 55-59°C
- Boiling point:
- 534.2±23.0 °C(Predicted)
- Density
- 1.09±0.1 g/cm3(Predicted)
- Flash point:
- 9℃
- storage temp.
- Desiccate at -20°C
- solubility
- DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Methanol: 30 mg/ml
- form
- A neat solid
- color
- white to beige
Safety Information
- Hazard Codes
- F,T
- Risk Statements
- 11-23/24/25-39/23/24/25-25
- Safety Statements
- 7-16-36/37-45
- RIDADR
- UN1230 - class 3 - PG 2 - Methanol, solution
- WGK Germany
- 1
- Hazardous Substances Data
- 209414-07-3(Hazardous Substances Data)
- DEA Controlled Substances
- CSCN: 7118
CSA SCH: Schedule I
NARC: No
1-Pentyl-3-(1-naphthoyl)indole Usage And Synthesis
Description
JWH 018 (CRM) (Item No. 27973) is a certified reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. JWH 018 (CRM) (Item No. 27973) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical Properties
White Powder
Uses
Analgesic Drug
Uses
JWH 018 is the 18th compound synthesized in a series of more than 470 analogs and metabolites of ?9-Tetrahydro- cannabinol (THC) (T293200), the active component of marijuana. JWH 018 acts as cannabinoid receptor. Controlled substance.
Definition
ChEBI: JWH 018 is an indolecarboxamide.
Biological Activity
Potent cannabinoid receptor agonist with mild selectivity for CB 2 (K i values are 2.94 and 9.0 nM for CB 2 and CB 1 receptors respectively).
References
[1] MARIE H DEVENTER. Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo-Pyridyl Synthetic Cannabinoid Receptor Agonist CH-FUBBMPDORA.[J]. Drug Testing and Analysis, 2025. DOI: 10.1002/dta.3854
[2] KATHARINA ELISABETH GRAFINGER. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays[J]. Drug Testing and Analysis, 2021, 13 7: 1412-1429. DOI: 10.1002/dta.3054
[3] ANNELIES CANNAERT. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA[J]. ACS Chemical Neuroscience, 2020, 11 24: 4434-4446. DOI: 10.1021/acschemneuro.0c00644