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XENIN

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XENIN Basic information

Product Name:
XENIN
Synonyms:
  • H-Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu-OH
  • XENIN 25 ACETATE SALT ≥95%
  • Human xenin
  • Human xenopsin
  • Xenopsin 25
  • L-Leucine,L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-a-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-
  • Xenin 25 acetate salt, ≥95% (HPLC)
  • L-Leucine, L-methionyl-L-leucyl-L-threonyl-L-lysyl-L-phenylalanyl-L-α-glutamyl-L-threonyl-L-lysyl-L-seryl-L-alanyl-L-arginyl-L-valyl-L-lysylglycyl-L-leucyl-L-seryl-L-phenylalanyl-L-histidyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-tryptophyl-L-isoleucyl-
CAS:
144092-28-4
MF:
C139H224N38O32S
MW:
2971.57
Product Categories:
  • Xenin 25
  • Hormones
  • Obesity Research
Mol File:
144092-28-4.mol
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XENIN Chemical Properties

storage temp. 
−20°C
solubility 
Soluble in DMSO
form 
Solid
color 
White to off-white
Sequence
Met-Leu-Thr-Lys-Phe-Glu-Thr-Lys-Ser-Ala-Arg-Val-Lys-Gly-Leu-Ser-Phe-His-Pro-Lys-Arg-Pro-Trp-Ile-Leu
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Safety Information

Safety Statements 
22-24/25
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XENIN Usage And Synthesis

Uses

Peptide involved in the regulation of food intake that is released into the circulation from the gut mucosa after a meal. It may stimulate enzyme release from the exocrine pancreas

Uses

Xenin 25 Acetate Salt can be used in biological study of hormonal responses to cholinergic input are different in humans with and without type 2 diabetes mellitus.

in vivo

Both intracerebroventricular and intraperitoneal administration of xenin inhibit fasting-induced hyperphagia in wild-type mice in a dose-dependent manner. The intraperitoneal injection of xenin also reduces nocturnal intake in ad libitum–fed wild-type mice. The intraperitoneal injection of xenin increases Fos immunoreactivity in hypothalamic nuclei, including the paraventricular nucleus and the arcuate nucleus. Xenin reduces food intake in agouti and ob/ob mice[2]. Gastric emptying rate is reduced by about 93% in xenin-treated mice compared to saline-treated control mice. The i.p. xenin injection significantly increases Fos-immunoreactive cells in the nucleus of the solitary tract of the brainstem, but not area postrema and dorsal motor nucleus of the vagus[3].

XENINSupplier

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