2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Chemical Properties

Melting point:

146.0 to 150.0 °C

Boiling point:

637.0±65.0 °C(Predicted)

Density 

1.70±0.1 g/cm3(Predicted)

storage temp. 

Refrigerator

solubility 

DMSO, Methanol

form 

Solid

pka

1.69±0.10(Predicted)

color 

Pale Green

InChIKey

HLVGVJFVAKPFOZ-GNVCDDJRNA-N

SMILES

[C@H]1(O[C@H](COC(=O)C)[C@@H](OC(=O)C)[C@H]1OC(=O)C)N1C=NC2C(Cl)=NC(N)=NC1=2 |&1:0,2,8,13,r|

Safety Information

HS Code 

2933599590

2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside Usage And Synthesis

Chemical Properties

Pale Green Solid

Uses

2′,3′,5′-Tri-O-acetyl-6-chloroguanosine diacetate is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

References

[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005

2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside(16321-99-6)Related Product Information

• 2-Amino-6-chloropurine Riboside
• 6-Chloropurine
• 6-Chloroguanine
• 2-AMINO-6-CHLORO-9-(BETA-D-2-DEOXYRIBOFURANOSYL)PURINE
• 2-Aminopurine
• 2-ACETAMIDO-6-CHLORO-9-(2',3',5'-TRI-O-ACETYL-BETA-D-RIBOFURANOSYL)PURINE
• 6-Chloropurine ribonucleoside
• 2',3',5'-Tri-O-acetyl-2-aMino-6-chloropurine Riboside
• 2-AMINO-9-(2-O-METHYL-BETA-D-RIBOFURANOSYL)PURINE
• 6-CHLOROPURINE-2'-DEOXYRIBOSIDE
• 6-CHLORO-9-(5-DEOXY-D-RIBOFURANOSYL)PURINE