S-Adenosyl-L-methionine Disulfate Tosylate Chemical Properties

Melting point:

>122°C (dec.)

storage temp. 

Inert atmosphere,Store in freezer, under -20°C

solubility 

DMSO (Slightly, Heated), Water (Sparingly)

form 

Solid

color 

White to Pale Yellow

Stability:

Hygroscopic

InChI

InChI=1/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/t7-,8+,10+,11+,14+,27?;;;/s3

InChIKey

XDCFCHNAIMYBAZ-DUXZMFTLNA-N

SMILES

S(C1C=CC(C)=CC=1)(O)(=O)=O.S(O)(O)(=O)=O.O[C@@H]1[C@@H]([C@@H](C[S+](C)CC[C@H](N)C(=O)O)O[C@H]1N1C=NC2C(=NC=NC1=2)N)O.S(O)([O-])(=O)=O |&1:17,18,19,25,31,r|

CAS DataBase Reference

97540-22-2(CAS DataBase Reference)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

HS Code 

2934990002

S-Adenosyl-L-methionine Disulfate Tosylate Usage And Synthesis

Chemical Properties

White to off-white powder

Uses

Ademetionine Disulfate Tosylate is the disulfate-tosylate mixed salt of a mixture of diastereoisomers of the ademetionine ions. Ademetionine possesses anti-inflammatory activity and has been used in treatment of chronic liver disease.

Uses

Ademetionine Disulfate Tosylate is used to study the survival time in various damage brain models.

Definition

The density of Ademethionine Disulfate Tosylate is typically between 1.42-1.48 g/cm³. Its unique characteristics make it an ideal compound for various health supplements and pharmaceuticals. The compound is commonly packaged in sealed containers and transported at controlled temperatures to ensure its integrity and purity. It is manufactured through synthetic procedures involving the reaction between adenosine triphosphate (ATP) and methionine. Ademethionine Disulfate Tosylate is typically used for its therapeutic effects, which range from improving liver function to providing relief from depression and arthritis. It is used extensively in treating liver diseases and is known to enhance liver cell regeneration, promote bile flow, and improve overall liver function. SAMe is also known for its anti-inflammatory properties, which make it effective in reducing the symptoms of conditions such as osteoarthritis and depression.

Application

S-Adenosyl-L-methionine Disulfate Tosylate (SAMe-ST) is the tosylate disulphate form of S-adenosyl-L-methionine (SAM).  SAM may serve as an adjunctive therapy for refractory major depressive disorder.  SAMe-ST is a multifunctional biochemical agent exhibiting antidepressant, anticancer and hepatoprotective properties.  It may be administered as a dietary supplement for the management of depressive disorders and hepatic conditions.

Biosynthesis

Ademethionine Disulfate Tosylate (SAME) is made in the body from methionine, an amino acid found in foods.

Biological Activity

Studies have shown that S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) at concentrations of 0.2 to 5.0 mg/ml protects red blood cells from hypotonic hemolysis, and that this protection is attributed to the SAMe moiety itself, rather than its Sulfate or mesylate moiety. SAMe-ST significantly increased Na+.K(+)-ATPase activity^[1].

Side effects

Ademethionine Disulfate Tosylate is likely safe. Side effects might include gas, diarrhea, constipation, dry mouth, headache, and nervousness, especially at higher doses.

References

[1] M TSUJI;K O;K Kodama. Protective effects of S-adenosyl-L-methionine against enzyme leakage from cultured hepatocytes and hypotonic hemolysis.[J]. Japanese journal of pharmacology, 1990. DOI:10.1254/jjp.52.45.

S-Adenosyl-L-methionine Disulfate Tosylate(97540-22-2)Related Product Information

• p-Toluenesulfonic acid
• Sodium p-toluenesulfonate
• L-Methionine
• S-ADENOSYL-L-METHIONINE
• DL-Methionine
• Adenosine
• S-adenosylmethionine
• ALTRENOGEST
• Betaine
• Sorafenib tosylate
• Sodium xylenesulfonate
• 4-CHLOROBENZOYLACETONITRILE
• 5'-DEOXY-S-ADENOSYL-L-HOMOCYSTEINE
• Glycine
• Citicoline sodium
• ATP disodium salt
• (S)-(-)-2-Methyl-2-propanesulfinamide
• (S)-2-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-3-cyanopropanoic acid