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2-Methyl-2-thiopseudourea sulfate

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2-Methyl-2-thiopseudourea sulfate Basic information

Product Name:
2-Methyl-2-thiopseudourea sulfate
Synonyms:
  • s-methylthiouroniumsulfate(2:1)
  • S-METHYL-ISO-THIOUREA
  • S-MethyliSothourea Sulfate
  • S-METHYLISOTHIOUREA HEMISULFATE NITRIC O XIDE SYNTHASE
  • S-Methylthioureasulfate=2-Methyl-2-thiopseudoureasulfate
  • 2-Methyl-2-thiopseudourea sulphate
  • S-EIT hemihydrate
  • S-Methylisothiouroniumsulfate,98%
CAS:
867-44-7
MF:
C2H8N2O4S2
MW:
188.23
EINECS:
212-759-7
Product Categories:
  • Cell Signaling and Neuroscience
  • Nitric Oxide and Cell Stress
  • Nitric Oxide Metabolism
  • Nitric Oxide Synthase Regulators
  • Bioactive Small Molecules
  • Building Blocks
  • pharmacetical
  • Nitric Oxide
  • Cell Biology
  • Chemical Synthesis
  • M
  • Organic Building Blocks
  • Sulfur Compounds
  • Thioureas
Mol File:
867-44-7.mol
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2-Methyl-2-thiopseudourea sulfate Chemical Properties

Melting point:
240-241 °C (dec.)(lit.)
Density 
1.28
Flash point:
3℃
storage temp. 
Inert atmosphere,Room Temperature
solubility 
H2O: 0.1 g/mL, clear, colorless
pka
pK1:9.83(+1) (25°C)
form 
Crystals or Crystalline Powder
color 
White
PH
5.5 (260g/l, H2O, 20℃)
Water Solubility 
260 g/L (20 ºC)
Sensitive 
Hygroscopic
BRN 
3917217
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
867-44-7(CAS DataBase Reference)
EPA Substance Registry System
Carbamimidothioic acid, methyl ester, sulfate (2:1) (867-44-7)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
22-24/25
WGK Germany 
3
RTECS 
UM9200000
TSCA 
Yes
HS Code 
29309070

MSDS

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2-Methyl-2-thiopseudourea sulfate Usage And Synthesis

Description

SMIT is a potent non-selective inhibitor of NOS isoforms in vitro but may lack good in vivo efficacy due to poor cellular penetration. The Ki values are 120, 200, and 160 nM using purified human iNOS, eNOS, and nNOS, respectively.

Chemical Properties

white crystalline powder

Uses

Intermediate of 4-Hydroxydebrisoquine. S-Methyl-isothiouronium Hemisulfate is also a reagent used in the synthesis of strobilurin-pyrimidine derivatives for their anti-proliferative activity.

Biochem/physiol Actions

More potent than NMMA as an inhibitor of inducible nitric oxide synthetase (iNOS).

2-Methyl-2-thiopseudourea sulfate Preparation Products And Raw materials

Preparation Products

5-methoxy-2-(methylthio)pyrimidin-4-ol ,97%4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile ,97%1-Methyl-3-nitro-1-nitrosoguanidine4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTEREthyl 4-chloro-2-methylthio-5-pyrimidinecarboxylateAminoguanidine bicarbonate1,4-DIHYDRO-2-(METHYLTHIO)-4-OXO-5-PYRIMIDINE-CARBOXYLATE ACID ETHYL ESTERIMINOCTADINE TRIACETATE5-CHLORO-2-METHOXYPYRIMIDINE-4-CARBOXYLIC ACID1,1-DIMETHYLGUANIDINE SULFATE5-[2-(METHYLTHIO)PYRIMIDIN-4-YL]THIOPHENE-2-SULFONYL CHLORIDE5-Chloro-2-(methylsulfonyl)pyrimidineMETHYL 5-BROMO-2-(METHYLSULFANYL)-4-PYRIMIDINECARBOXYLATE, 974-Methoxy-6-methyl-2-(methylsulfonyl)pyrimidine ,97%5-CHLORO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID5-Bromo-4-chloro-2-(methylthio)-7H-pyrrolo[2,3-D]pyrimidine ,97%5-BROMO-2-(METHYLSULFONYL)PYRIMIDINE-4-CARBOXYLIC ACID2-(METHYLTHIO)-4-(TRIFLUOROMETHYL)PYRIMIDINE4-(Trifluoromethyl)-2-(methylthio)pyrimidine-5-carboxylic acid ,97%4-Hydroxy-2-(methylthio)pyrimidine-5-carbonitrile ,97%3-OXO-3-THIOPHEN-2-YL-PROPIONIC ACID ETHYL ESTER5-AMINOPYRIMIDINE5-Bromo-2-(methylthio)pyrimidine-4-carboxylic acidethyl 2-(methylsulfanyl)-4-(trifluoromethyl)pyrimidine-5-carboxylate4-Methoxy-6-methyl-2-(methylthio)pyrimidine4-METHYL-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER2-(METHYLSULFANYL)-5-PHENYLPYRIMIDINE5-Methyl-2-(methylsulfonyl)pyrimidine ,97%Aminoguanidinium sulphate2-(METHYLTHIO)ETHANOL1-(4-METHYL-2-(METHYLTHIO)PYRIMIDIN-5-YL)ETHANONEGabexate mesylate4-AMINO-2-METHYLSULFANYL-PYRIMIDINE-5-CARBOXYLIC ACIDETHYL 2-(ETHYLTHIO)-4-HYDROXYPYRIMIDINE-5-CARBOXYLATE5-METHYL-2-METHYLSULFANYL-PYRIMIDINE4-Chloro-6-methyl-2-(methylthio)pyrimidine

2-Methyl-2-thiopseudourea sulfateSupplier

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