Ethanamine, 2-(3-pyridinyloxy)- (9CI) Chemical Properties

Boiling point:

258.8±20.0 °C(Predicted)

Density 

1.089±0.06 g/cm3(Predicted)

storage temp. 

2-8°C(protect from light)

pka

8.08±0.10(Predicted)

Appearance

Colorless to light yellow Liquid

InChI

InChI=1S/C7H10N2O/c8-3-5-10-7-2-1-4-9-6-7/h1-2,4,6H,3,5,8H2

InChIKey

WKMLARMIRUVDDF-UHFFFAOYSA-N

SMILES

C(N)COC1=CC=CN=C1

Ethanamine, 2-(3-pyridinyloxy)- (9CI) Usage And Synthesis

Synthesis

General procedure for the synthesis of 3-(2-aminoethoxy)pyridine using 2-(pyridin-3-yloxy)acetonitrile (CAS: 266348-17-8) as starting material: 2-(pyridin-3-yloxy)acetonitrile (100 mg, 0.75 mmol), K2CO3 (103 mg, 0.75 mmol), DMSO was sequentially added in a 100 mL two-neck flask (0.1 mL) and H2O (2 mL). The reaction system was placed in an ice bath and 30% H2O2 (0.1 mL) was added slowly and dropwise. Subsequently, the reaction mixture was stirred at room temperature for 5 min, after which the solvent was removed by evaporation. The crude product was purified by column chromatography using ethyl acetate as eluent to give the final white solid product 3-(2-aminoethoxy)pyridine (62.2 mg, 55% yield).

References

[1] Patent: TWI607995, 2017, B. Location in patent: Page/Page column 183