Dehydrocostus lactone Chemical Properties

Melting point:

57.0 to 61.0 °C

Boiling point:

140-143 °C(Press: 0.5 Torr)

Density 

1.09

storage temp. 

Sealed in dry,Store in freezer, under -20°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly)

form 

Solid

color 

White to Off-White

Odor

nutty

optical activity

[α]/D -14.0±3.0°, c = 1 in chloroform

λmax

206nm(MeOH)(lit.)

InChIKey

NETSQGRTUNRXEO-XUXIUFHCSA-N

LogP

1.480 (est)

CAS DataBase Reference

477-43-0(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

HS Code 

29322090

Dehydrocostus lactone Usage And Synthesis

Description

Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells. It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.

Description

A guaianolide sesquiterpene lactone extracted from costus oil. Dehydrocostuslactone is one of the components of lactone-mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Uses

Dehydrocostus lactone is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.

Uses

Dehydrocostus Lactone is a compound known to be a growth regulator in plants. Known to affect cell viability and cell cycle distribution it may be useful in the application towards drug-resistant tumors.

Definition

ChEBI: An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.

Contact allergens

A guaianolide sesquiterpene lactone extracted from costus oil. It is one of the components of Lactone mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Dehydrocostus lactone(477-43-0)Related Product Information

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