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Dehydrocostus lactone

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Dehydrocostus lactone Basic information

Product Name:
Dehydrocostus lactone
Synonyms:
  • EPILIGULYL OXIDE
  • DEHYDROCOSTUSLACTONE
  • DEHYDROCOSTUS LACTONE hplc
  • (3aS,6aR,9aR,9bS)-Decahydro-3,6,9-tris(methylene)azuleno[4,5-b]furan-2(3H)-one
  • DEHYDROCOSTUNOLIDE
  • Azuleno[4,5-b]furan-2(3H)-one,decahydro-3,6,9-
  • Costus lactone, dehydro-
  • tris(methylene)-,(3aS,6aR,9aR,9bS)-
CAS:
477-43-0
MF:
C15H18O2
MW:
230.3
Product Categories:
  • Sesquiterpenoids
  • Inhibitors
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • Heterocycles
  • standardized herbal extract
Mol File:
477-43-0.mol
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Dehydrocostus lactone Chemical Properties

Melting point:
57.0 to 61.0 °C
Boiling point:
140-143 °C(Press: 0.5 Torr)
Density 
1.09
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
form 
Solid
color 
White to Off-White
Odor
nutty
optical activity
[α]/D -14.0±3.0°, c = 1 in chloroform
λmax
206nm(MeOH)(lit.)
InChIKey
NETSQGRTUNRXEO-XUXIUFHCSA-N
LogP
1.480 (est)
CAS DataBase Reference
477-43-0(CAS DataBase Reference)
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Safety Information

Safety Statements 
24/25
HS Code 
29322090
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Dehydrocostus lactone Usage And Synthesis

Description

Dehydrocostus lactone is a natural sesquiterpene first isolated from costus root, which is used in traditional medicine. Dehydrocostus lactone has diverse anti-cancer properties in cells and animal models, causing cell cycle arrest, inducing apoptosis, diminishing multidrug resistance, and suppressing angiogenesis in cancer cells. It also has anti-inflammatory actions in cells, including the inhibition of signaling through STAT1 and STAT3.

Description

A guaianolide sesquiterpene lactone extracted from costus oil. Dehydrocostuslactone is one of the components of lactone-mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Uses

Dehydrocostus lactone is the oil extracted from Saussurea lappa is used in perfumery and in the Orient for all kinds of diseases.

Uses

Dehydrocostus Lactone is a compound known to be a growth regulator in plants. Known to affect cell viability and cell cycle distribution it may be useful in the application towards drug-resistant tumors.

Definition

ChEBI: An organic heterotricyclic compound and guaianolide sesquiterpene lactone that is acrylic acid which is substituted at position 2 by a 4-hydroxy-3,8-bis(methylene)decahydoazulen-5-yl group and in which the hydroxy group and the carboxy group have undergone formal condensation to afford the corresponding gamma-lactone.

Contact allergens

A guaianolide sesquiterpene lactone extracted from costus oil. It is one of the components of Lactone mix, with costunolide and alantolactone, used to detect Compositae-sensitive patients.

Dehydrocostus lactoneSupplier

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