compoundk
compoundk Basic information
- Product Name:
- compoundk
- Synonyms:
-
- Aids096249
- Aids-096249
- L-754,394
- N-(2(R)-Hydroxy-1(S)-indany)-2(R)-phenylmethyl-4(S)-hydroxy-5-(1-(4-(5-furo[2,3-B]pyridylmethyl)- 2(S)-N'-(tert-butylcarboxamido)piperazinyl)) pentanamide
- (2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-5-[[(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]amino]-5-oxopentyl]-N-tert-butyl-4-(furo[2,3-b]pyridin-5-ylmethyl)piperazine-2-carboxamide
- D-erythro-Pentonamide, 2,3,5-trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(furo[2,3-b]pyridin-5-ylmethyl)-1-piperazinyl]-2-(phenylmethyl)-
- 394
- L 754
- CAS:
- 160729-91-9
- MF:
- C38H47N5O5
- MW:
- 653.81
- Mol File:
- 160729-91-9.mol
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compoundk Chemical Properties
- Melting point:
- 184-185 °C
- Boiling point:
- 903.1±65.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 14.39±0.40(Predicted)
- InChIKey
- UBUFVRJUGFJQSI-AMKZAOGANA-N
- SMILES
- O=C(NC(C)(C)C)[C@@H]1CN(CC2C=C3C=COC3=NC=2)CCN1C[C@H](C[C@H](C(=O)N[C@H]1C2C=CC=CC=2C[C@H]1O)CC1C=CC=CC=1)O |&1:7,24,26,30,38,r|
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compoundk Usage And Synthesis
Uses
HIV-IN-11 is part of the hydroxylaminoglutaramide (HAPA) transition state isomeric series of HIV protease inhibitors and is a potent and selective inhibitor of HIV-1 protease. HIV-IN-11 competitively inhibits HIV-1 PR (Ki: 0.049 nM) and potently inhibits replication of HIV(IIIb)-infected MT4 lymphocytes at concentrations of 25.0-50.0 nM. HIV-IN-11 displays a longer half-life than indinavir sulfate in animal models and serves as a promising second-generation HIV protease inhibitor[1].
References
[1] Dorsey BD, et al. Identification of MK-944a: a second clinical candidate from the hydroxylaminepentanamide isostere series of HIV protease inhibitors. J Med Chem. 2000 Sep 7;43(18):3386-99. DOI:10.1021/jm9903848
compoundkSupplier
Chengdu Peter-like Biotechnology Co., Ltd. Gold
- Tel
- 028-81700200 13308200041
- 2851167782@qq.com
LGM Pharma
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- 1-(800)-881-8210
- inquiries@lgmpharma.com
Nanjing Spring & Autumn Biological Engineering Co., Ltd.
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
Nanjing Digger Medical Technology Co. Ltd.
- Tel
- 025-025-51191215 18013836722
- 2399235533@qq.com
TargetMol Chemicals Inc.
- Tel
- +1-781-999-5354; +17819995354
- marketing@targetmol.com