PAC1
PAC1 Basic information
- Product Name:
- PAC1
- Synonyms:
-
- PAC1
- 4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide
- PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide
- 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide
- PAC-1,PAC1
- Procaspase activating coMpound 1
- (E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide
- 4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1
- CAS:
- 315183-21-2
- MF:
- C23H28N4O2
- MW:
- 392.49
- Product Categories:
-
- Inhibitor
- Inhibitors
- Mol File:
- 315183-21-2.mol
PAC1 Chemical Properties
- Density
- 1.14
- storage temp.
- Store at +4°C
- solubility
- DMSO: ≥10mg/mL
- form
- solid
- pka
- 8.82±0.40(Predicted)
- color
- white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.
Safety Information
- Hazard Codes
- Xn,N
- Risk Statements
- 22-36/37/38-50/53
- Safety Statements
- 26-36/37-60-61
- RIDADR
- UN 3077
- WGK Germany
- 3
- HS Code
- 29335990
PAC1 Usage And Synthesis
Description
PAC-1 (315183-21-2) is a procaspase-activating compound, directly activating procaspase-3, producing caspase-3, EC50=0.22 μM.1 It is less potent at activating procaspase-7, EC50=4.5 μM. It induces apoptosis in a variety of cancer cell lines. The mechanism of activation involves sequestering inhibitory zinc ions thus allowing procaspase-3 to autoactivate.2?? Sensitizes cancer cells to various chemotherapeutic agents.3
Uses
PAC-1 is a potent procaspase-3 activator with EC50 of 0.22 μM.
Biological Activity
Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC 50 = 0.22 μ M). Also activates procaspase-7 in a less efficient manner (EC 50 = 4.5 μ M). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC 50 values are 0.003-1.41 and 5.02-9.98 μ M respectively).
storage
+4°C
References
[1] KARSON S PUTT. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy[J]. Nature chemical biology, 2006, 2 10: 543-550. DOI:10.1038/nchembio814
[2] QUINN P. PETERSON . PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition[J]. Journal of Molecular Biology, 2009, 388 1: Pages 144-158. DOI:10.1016/j.jmb.2009.03.003
[3] RACHEL C. BOTHAM. Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics[J]. ACS Central Science, 2016, 2 8: 545-559. DOI:10.1021/acscentsci.6b00165
PAC1Supplier
- Tel
- sales@boylechem.com
- Tel
- 18210857532; 18210857532
- jkinfo@jkchemical.com
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
- Tel
- 0757-86329057 18934348241
- sales4.gd@hwrkchemical.com
- Tel
- 13817811078
- sales@jingyan-chemical.com
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- PAC1