2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR Chemical Properties

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

crystalline solid

color 

Very dark red

Safety Information

HS Code 

2933399990

2-AMINO-3-HYDROXY-4-BROMOPYRIDINE HBR Usage And Synthesis

Synthesis

General procedure for the synthesis of 2-amino-4-bromopyridin-3-ol hydrobromide from 2-amino-3-hydroxypyridine: Bromine (11.2 mL, 0.21 mol) was slowly added dropwise to a mechanically stirred suspension of 2-amino-3-hydroxypyridine (20 g, 0.18 mol) in acetic acid (300 mL) at 5-10 °C, after which the reaction system was brought to room temperature. The reaction mixture was heated to 120-125 °C, maintained for 12 h and then concentrated to give the crude product. The crude product was ground with ether (50 mL x 3) and subsequently dried under vacuum to afford 2-amino-4-bromopyridin-3-ol hydrobromide as a dark brown solid, which could be used in subsequent reactions without further purification. Yield: 48.5 g; MS (m/z): 189.3, 191.1 ([M + H]+).

References

[1] Patent: WO2018/42362, 2018, A1. Location in patent: Page/Page column 125

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