4-Formyl-2-isopropylthiazole Chemical Properties

Boiling point:

232.4±13.0 °C(Predicted)

Density 

1.159±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

1.10±0.10(Predicted)

InChI

InChI=1S/C7H9NOS/c1-5(2)7-8-6(3-9)4-10-7/h3-5H,1-2H3

InChIKey

NUEZKCPTDMEROB-UHFFFAOYSA-N

SMILES

S1C=C(C=O)N=C1C(C)C

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

WGK Germany 

3

HS Code 

2934100090

4-Formyl-2-isopropylthiazole Usage And Synthesis

Synthesis

A solution of 3.1 g (15.6 mmol) of ethyl 2-isopropylthiazole-4-carboxylate in 50 ml of dichloromethane was cooled under N2 atmosphere to -78° C and treated dropwise with 15.6 ml (23.4 mmol) of a 1.5 M solution of diisobutylaluminum hydride in toluene over 1.5 h. After being stirred for an additional 0.5 h, the solution was quenched with 5 ml of methanol followed by 15 ml of aqueous Rochelle's salt. The resulting mixture was partitioned between chloroform and aqueous Rochelle's salt, dried over Na2SO4, and concentrated to provide 1.37 g (56 %) of the crude 4-Formyl-2-isopropylthiazole.

4-Formyl-2-isopropylthiazole(133047-46-8)Related Product Information

• 2-CYCLOPROPYL-THIAZOLE-4-CARBOXYLIC ACID
• siomycin
• 4-Formyl-2-isopropylthiazole
• TERT-BUTYL 4-(4-FORMYL-1,3-THIAZOL-2-YL)TETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
• 2-[1-(TERT-BUTOXYCARBONYL)-4-PIPERIDINYL]-1,3-THIAZOLE-4-CARBOXYLIC ACID
• THIOSTREPTON
• tert-Butyl 4-[4-(ethoxycarbonyl)-1,3-thiazol-2-yl]tetrahydro-1(2H)-pyridinecarboxylate