Asiaticoside Chemical Properties

Melting point:

235-238°C

alpha 

D20 -14° (alc)

Boiling point:

1017.5±65.0 °C(Predicted)

Density 

1.44±0.1 g/cm3(Predicted)

vapor pressure 

0.001Pa at 160℃

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

solubility 

DMSO (Slightly), Ethanol (Slightly, Heated, Sonicated), Methanol (Slightly)

pka

12.50±0.70(Predicted)

form 

Solid

color 

Crystals

Water Solubility 

99mg/L

InChIKey

WYQVAPGDARQUBT-KRQXBQLUNA-N

LogP

0.44 at 22℃

CAS DataBase Reference

16830-15-2(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

RIDADR 

UN 2811 6.1 / PGIII

WGK Germany 

3

RTECS 

YU9625000

F 

1-10

HS Code 

29389090

MSDS

• Language:English Provider:[6-[[3,4-Dihydroxy-6-(hydroxymethyl)-5-(3,4,5-trihydroxy-6-methyl-oxan-2-yl)oxy-oxan-2-yl]oxymethyl]-3,4,5-trihydroxy-oxan-2-yl] (1S,2R,4aS,6aS,6bR,9S,10R,11R,12aS,14bR)-10,11-dihydroxy-9-(hydroxymethyl)-1,2,6a,6b,9,12a-hexamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene-4a-carboxylate
• Language:English Provider:SigmaAldrich

Asiaticoside Usage And Synthesis

Description

Asiaticoside is the main saponin constituent of C. asiatica, a plant long used in the Ayurvedic system of medicine to treat a variety of ailments including dermatitis, diabetes, cough, cataract, hypertension, as well as for wound healing and improving memory. In various wound healing models, topical application (0.2-0.4%), injection (1 mg), or ingestion (1 mg/kg) of asiaticoside has been shown to increase hydroxyproline content, improve tensile strength, increase collagen synthesis and remodeling of the collagen matrix, promote epithelialization, stimulate glycosaminoglycan synthesis, and elevate antioxidant levels.

Chemical Properties

White powder

Uses

wound healing, anxiolytic

Uses

Asiatic Acid is a terpenoid saponin component isolated from Centella asiatica with antioxidant and anti-inflammatory activities. Asiaticoside has been shown to possess strong wound-healing properties and reduces scar formation.

Definition

ChEBI: Asiaticoside is a triterpenoid saponin.

Flammability and Explosibility

Not classified

Biological Activity

Asiaticoside, a triterpenoid compound from Centella asiatica, has been shown to have anti-inflammatory, anti-renal fibrosis and tissue repair promoting effects. Asiaticoside has been shown through ex vivo and in vivo studies to reduce blood urea nitrogen (BUN) and serum creatinine (Scr) levels in a renal ischemia-reperfusion injury (IRI) model ^[1]. Meanwhile, Asiaticoside decreased the secretion of IL-6, IL-1β, and TNF-α, but increased the secretion of IL-10 using a dose-dependent manner. Treatment of Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effect was attenuated by the administration of asiaticoside. In addition, asiaticoside significantly inhibits LPS-induced expression of inducible nitric oxide synthase (iNOS) and promotes expression of the polarisation marker protein arginase 1. It is also a potential candidate for use as a dental wound healing agent with a maximum tolerated concentration of 0.25 mg/ml, and its mechanism of action may be related to increased Col1A1 gene expression ^[2].

Safety Profile

Questionable carcinogen withexperimental tumorigenic data. When heated todecomposition it emits acrid smoke and fumes. Promoteshealing of wounds.

storage

+4°C

References

[1] XINGYING ZHAO, JINGWEN ZHOU*; Elucidation of the Biosynthesis of Asiaticoside and Its Reconstitution in Yeast[J]. ACS Sustainable Chemistry & Engineering, 2024, 12 10: 4028-4040. DOI:10.1021/acssuschemeng.3c07046.
[2] W. H. SURIYAH. In Vitro Wound Healing Effect of Asiaticoside Extracted from Centella asiatica (‘Pegaga’) on Human Gingival Fibroblast Cell Line[J]. Materials Science Forum, 2021, 72 1: 224-229. DOI:10.4028/www.scientific.net/MSF.1025.224.

Asiaticoside(16830-15-2)Related Product Information

• Asiaticoside
• Kresoxim-methyl
• Centella asiatica extract
• Methyl acetate
• Bensulfuron methyl
• Thiophanate-methyl
• METSULFURON METHYL
• Methyl salicylate
• Methylparaben
• Rotundine
• Sophoricoside
• Ursolic acid
• Asiaticoside B
• Methyl
• Centella asiatica whole plant
• Methyl bromide
• GLYCEROL MONOISOSTEARATE
• Hydroxy asiaticoside
• Madecassol