NU6140 Chemical Properties

Boiling point:

707.8±70.0 °C(Predicted)

Density 

1.234±0.06 g/cm3(Predicted)

storage temp. 

Desiccate at +4°C

solubility 

DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml

form 

White to off-white solid.

pka

9.41±0.10(Predicted)

color 

White to light yellow

NU6140 Usage And Synthesis

Uses

NU 6140 is a cyclin-dependant kinase 2 inhibitor which demonstrates 10-36 fold selectivity against Cdk2-cyclin A. This selectivity induces cell-cycle arrest at the G2-M phase and potentiates the apoptotic effect of pacitaxel.

Biological Activity

NU6140 is a CDK2 inhibitor with 10-36-fold selectivity over other CDK family members. NU6140 induces apoptosis and cell cycle arrest in cancer cells in the G2-M phase, and potentiates the cytotoxic effects of paclitaxel.', 'NU6140 is known to downregulate the expression of survivin protein, which possesses antiapoptotic activity and is generally overexpressed in cancer cells.

IC 50

cdk2-cyclin A: 0.41 μM (IC₅₀); CDK1-Cyclin B: 6.6 μM (IC₅₀); CDK4-Cyclin D: 5.5 μM (IC₅₀); cdk5-p25: 15 μM (IC₅₀); cdk7-cyclin H: 3.9 μM (IC₅₀); Aurora A: 67 nM (IC₅₀); Aurora B: 35 nM (IC₅₀)

storage

Desiccate at +4°C

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