Imirestat
Imirestat Basic information
- Product Name:
- Imirestat
- Synonyms:
-
- Imirestat
- 2,7-Difluorospiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione
- AL-1576
- HOE-843
- 2,7-Difluorospiro[Fluorene-9,4'-IMidazolidine]-2',5'-Dione
- Alcon 1576
- 2,7-Difluoro-2'H,5'H-spiro[fluorene-9,4'-imidazolidine]-2',5'-dione
- Spiro[9H-fluorene-9,4'-imidazolidine]-2',5'-dione, 2,7-difluoro-
- CAS:
- 89391-50-4
- MF:
- C15H8F2N2O2
- MW:
- 286.23
- Mol File:
- 89391-50-4.mol
Imirestat Chemical Properties
- Density
- 1.58±0.1 g/cm3(Predicted)
- solubility
- DMSO: Soluble: =10 mg/ml
- form
- Solid
- pka
- 8.17±0.20(Predicted)
- color
- White to off-white
Imirestat Usage And Synthesis
Uses
Imirestat (AL 1576) is an aldose reductase inhibitor, used for the treatment of diabetes.
in vivo
Imirestat (1 mg/kg) improves nerve conduction velocity but is without effect upon the resistance to hypoxic conduction blockade or the deficit in insulin-stimulated oubain-sensitive ATPase activity[1].
References
[1] Carrington AL, et al. Aldose reductase inhibition with imirestat-effects on impulse conduction and insulin-stimulation of Na+/K(+)-adenosine triphosphatase activity in sciatic nerves of streptozotocin-diabetic rats. Diabetologia. 1991 Jun;34(6):397-401. DOI:10.1007/BF00403177
[2] BRENDA WALKER GRIFFIN. Effects of two new aldose reductase inhibitors, AL-1567 and AL-1576, in diabetic rats[J]. Metabolism: clinical and experimental, 1987, 36 5: Pages 486-490. DOI: 10.1016/0026-0495(87)90048-5
[3] PETER F. KADOR. Efficacy of Structurally Diverse Aldose Reductase Inhibitors on Experimental Periodontitis in Rats[J]. Journal of periodontology, 2011, 82 6: 926-933. DOI: 10.1902/jop.2010.100442
[4] P F KADOR. Relative importance of aldose reductase versus nonenzymatic glycosylation on sugar cataract formation in diabetic rats.[J]. Journal of Ocular Pharmacology and Therapeutics, 2000, 16 2: 149-160. DOI: 10.1089/jop.2000.16.149
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Imirestat(89391-50-4)Related Product Information
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- Imirestat
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- (3-fluorophenyl)(phenyl)methylamine
- 2-FLUOROFLUORENE
- 9H-Fluorene-9-carboxylic acid amide
- (RS)-1-(3-FLUOROPHENYL)ETHYLAMINE
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