Apigenin-D5
Apigenin-D5 Basic information
- Product Name:
- Apigenin-D5
- Synonyms:
-
- Apigenin-D5
- [3,6,8,35d5]-Apigenin
- 4',5,7-Trihydroxyflavone-d5
- 5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one-d5
- Pelargidenon 1449-d5
- Apigenin-d5 (Major)
- 3,6,8-trideuterio-2-(3,5-dideuterio-4-hydroxyphenyl)-5,7-dihydroxychromen-4-one
- 4H-1-Benzopyran-4-one-3,6,8-d3, 5,7-dihydroxy-2-(4-hydroxyphenyl-3,5-d2)-
- CAS:
- 263711-74-6
- MF:
- C15H5D5O5
- MW:
- 0
- Product Categories:
-
- Isotope Labelled Compounds
- Inhibitors
- Isotope Labeled Compounds
- Mol File:
- 263711-74-6.mol
Apigenin-D5 Chemical Properties
- Melting point:
- 345-350°C
- storage temp.
- -20°C Freezer
- solubility
- DMSO (Slightly), Ethanol (Slightly, Heated), Methanol (Slightly)
- form
- Solid
- color
- Pale Yellow to Yellow
Apigenin-D5 Usage And Synthesis
Description
Apigenin-d5 is an internal standard for the quantificaiton of apigenin by GC- or LC-MS. Apigenin is a flavonoid compound found in many fruits and vegetables that selectively inhibits casein kinase 2 (CK2). Apigenin inhibits CK2 activity in the renal cortex with an IC50 value of 30 μM to improve renal function in a rat model of glomerulonephritis. CK2 inhibition by 20 μM apigenin decreases the degradation of IκBα and down-regulates NF-κB levels in WEHI-231 cells. Apigenin, at 5 μM, is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression by 56% and 64%, respectively, in the macrophage cell line J774A.1.
Chemical Properties
Pale Yellow Crystalline Solid
Uses
The labelled aglucon of apiin and of apigenin-7-glucoside
Apigenin-D5Supplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- 0755-83725681-603
- Tel
- +86-400-002-6226 13028896684
- sales@rrkchem.com
- Tel
- +86-0371-86658258 15093356674;
- laboratory@coreychem.com