L-Menthyl acetate Chemical Properties

Melting point:

<25 °C

alpha 

-81°(20/D, c=8, C6H6)

Boiling point:

229-230 °C(lit.)

Density 

0.92 g/mL at 25 °C(lit.)

vapor pressure 

45Pa at 20℃

FEMA 

2668 | MENTHYL ACETATE (ISOMER UNSPECIFIED)

refractive index 

n20/D 1.447(lit.)

Flash point:

171 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Liquid

Specific Gravity

0.922

color 

Colourless

Odor

at 100.00 %. mentholic minty herbal tea fruity woody floral earthy

Odor Type

mentholic

optical activity

[α]20/D 81°, c = 8 in benzene

Water Solubility 

23.2mg/L at 20℃

JECFA Number

431

Merck 

14,5839

BRN 

2208505

LogP

4.39 at 25℃

CAS DataBase Reference

2623-23-6(CAS DataBase Reference)

EPA Substance Registry System

Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate, (1R,2S,5R)- (2623-23-6)

Safety Information

Safety Statements 

24/25

RIDADR 

NA 1993 / PGIII

WGK Germany 

3

RTECS 

AI5900000

TSCA 

Yes

HS Code 

2915 39 00

Toxicity

LD50 orally in Rabbit: > 5000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

L-Menthyl acetate Usage And Synthesis

Chemical Properties

(1R)-(-)-Menthyl acetate occurs in peppermint oils. It is a colorless liquid with a fresh, fruity, peppermint odor.
(?)-Menthyl acetate is prepared by acetylation of (?)-menthol (e.g., with acetic anhydride). It is used mainly in peppermint flavors and reconstituted peppermint oils, but also to a small extent in perfumery.

Uses

L-Menthyl Acetate, and its derivatives, is used as a penetration enhancers, to enhance the skin permeation of various drugs with differing lipophilicities, such as 5-aminolevulinic acid (ALA), 5-fluorouracil (5-FU), isosorbide dinitrate (ISDN), lidocaine (LD), etc.

Definition

ChEBI: (-)-Menthyl acetate is a p-menthane monoterpenoid.

Flammability and Explosibility

Not classified

Biochem/physiol Actions

Taste at 25 ppm

Safety Profile

Low toxicity by ingestion and skin contact. A skin irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Synthesis

L-Menthyl acetate is produced by direct esterification of racemicMenthol with Acetic acid under azeotropic conditions.

L-Menthyl acetate(2623-23-6)Related Product Information

• Vinyl acetate
• 2-Methyl-2-propenoic acid cyclohexyl ester
• 4-tert-Butylcyclohexyl acetate
• 1-Methylcyclohexanol
• Linalyl acetate
• (1R)-(-)-Menthyl glyoxylate hydrate
• POLY(VINYL ACETATE)
• 2-Butanone oxime
• Benzyl acetate
• Isobornyl acetate
• Sodium acetate
• Ethyl acetate
• PHENYL ACETATE
• Isopropyl acetate
• Magnesium acetate
• Triacetin
• METHYLCYCLOHEXANONE
• Ammonium acetate