Cyclophosphamide-d4
Cyclophosphamide-d4 Basic information
- Product Name:
- Cyclophosphamide-d4
- Synonyms:
-
- Cyclophosphamide-d4
- Cyclostin-d4
- Cytoxan-d4
- Endoxan-d4
- Genoxal-d4
- Hexadrin-d4
- Mitoxan-d4
- N,N-Bis(2-chloroethyl)tetrahydro-4,5-d2-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide
- CAS:
- 173547-45-0
- MF:
- C7H15Cl2N2O2P
- MW:
- 261.08
- EINECS:
- 244-379-2
- Product Categories:
-
- Intermediates & Fine Chemicals
- Isotope Labeled Compounds
- Pharmaceuticals
- Phosphorylating and Phosphitylating Agents
- Isotope Labelled Compounds
- Isotope Labelled Compounds, Pharmaceuticals, Intermediates & Fine Chemicals, Phosphorylating and Phosphitylating Agents, Phosphorylating and Phosphitylating Agents
- Mol File:
- 173547-45-0.mol
Cyclophosphamide-d4 Chemical Properties
- Melting point:
- 41-450C
- storage temp.
- -20°C Freezer
- solubility
- Chloroform: Slightly Soluble,Methanol: Slightly Soluble
- form
- A solid
Cyclophosphamide-d4 Usage And Synthesis
Description
Cyclophosphamide-d4 contains four deuterium atoms. It is intended for use as an internal standard for the quantification of cyclophosphamide by GC- or LC-MS. Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders. In cells with low levels of aldehyde dehydrogenase, cyclophosphamide acts as a prodrug and is metabolized to the active compound phosphoramide mustard, which crosslinks with DNA and causes cell death.
Chemical Properties
White to Off-White Solid
Uses
Cyclophosphamide-d4 is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. Cyclophosphamide-d4 cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity. This substance is listed as a known human carcinogen.
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