Chlorozotocin Chemical Properties

Melting point:

147-148° (dec with the evolution of gas); mp 140-141° (dec)

Boiling point:

119.3°C (rough estimate)

Density 

1.6475 (rough estimate)

refractive index 

1.6000 (estimate)

pka

9.08±0.46(Predicted)

IARC

2A (Vol. 50) 1990

EPA Substance Registry System

Chlorozotocin (54749-90-5)

Safety Information

RIDADR 

3249

HazardClass 

6.1(b)

PackingGroup 

III

Hazardous Substances Data

54749-90-5(Hazardous Substances Data)

Chlorozotocin Usage And Synthesis

Chemical Properties

Chlorozotocin is a nitrosourea compound that exists as ivory-coloredcrystals at room temperature. It is soluble in water and is stable in solution at room temperature for up to 3 hours and under refrigeration for 24 hours. The powder form of chlorozotocin is stable under refrigeration for two years. The spontaneous, nonenzymatic degradation of chlorozotocin results in formation of DNA-alkylating and protein-carbamoylating moieties (Chabner et al. 2001).

Uses

Chlorozotocin is a cytostatic agent that has been used to treat melanoma and multiple myeloma and cancer of the stomach, large intestine, pancreas, and lung (IARC 1990).

Definition

ChEBI: Chlorozotocin is an amino sugar.

Safety Profile

Confirmed carcinogen with experimental carcinogenic and tumorigenic data. Poison by subcutaneous, intravenous, and intraperitoneal routes. Human systemic effects by intravenous route: anorexia, leukopenia, nausea or vomiting, thrombocytopenia. Mutation data reported. When heated to decomposition it emits very toxic fumes of Cland NOx. See also NITROSAMINES.

Carcinogenicity

Chlorozotocin is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals and because it is a member of a well-defined, structurally related class of substances listed in the Report on Carcinogensas either known to be a human carcinogen or reasonably anticipated to be a human carcinogen.

Chlorozotocin(54749-90-5)Related Product Information

• 1-(2-chloroethyl)-1-nitrosourea
• N,N'-dimethylnitrosourea
• 1,3-diethyl-1-nitrosourea
• Streptozotocin
• Chlorozotocin
• D-Glucosamine hydrochloride
• 1-Methyl-1-nitrosourea
• N-NITROSOMETHYL-2-CHLOROETHYLAMINE
• N-NITROSO-N-ETHYLUREA
• 1-nitroso-1-ethyl-3-methylurea
• elmustine